4TXA


Conserved Protein Domain Family
mRING-HC-C3HC3D_Roquin

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cd16638: mRING-HC-C3HC3D_Roquin 
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Modified RING finger, HC subclass (C3HC3D-type), found in Roquin-1, Roquin-2, and similar proteins
This family corresponds to the ROQUIN family of proteins, including Roquin-1, Roquin-2, and similar proteins, which localize to the cytoplasm and upon stress are concentrated in stress granules. They may play essential roles in preventing T-cell-mediated autoimmune disease and in microRNA-mediated repression of inducible costimulator (Icos) mRNA. They function as E3 ubiquitin ligases consisting of an N-terminal modified C3HC3D-type RING-HC finger with a potential E3 activity, a highly conserved ROQ domain required for RNA binding and localization to stress granules, and a CCCH-type zinc finger involved in RNA recognition.
Statistics
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PSSM-Id: 319552
View PSSM: cd16638
Aligned: 13 rows
Threshold Bit Score: 83.9347
Threshold Setting Gi: 443687451
Created: 2-May-2013
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding sitemodified
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Structure:4TXA; Mus musculus Roquin binds two Zn2+ ions, contacts at 4A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
Feature 1            #  #               # #  #           #  # 
4TXA_A         11 FLSCPICTQTFDetirkPISLGCGHTVCKMCLNKLhrkaCPFDQ 54
gi 24665272    11 FLNCPICCNEFAasqrcPVSLGCGHTICKLCLTTLynrqCPFDQ 54
gi 73621223    11 FLSCPICYNEFDenvhkPISLGCSHTVCKTCLNKLhrkaCPFDQ 54
gi 229273338   11 FLSCPICYNEFNenqrkPISLGCGHTVCQTCLGQFhskqCPFDQ 54
gi 198416684   23 FLICSVCENEFNrtdrcPISLGCGHTVCRGCLGDLkhpqCQFDQ 66
gi 918295673   11 FLSCPVCCNLFNeqyyrPISLGCGHTVCKSCLSKLhskkCLFDQ 54
gi 215508003   11 FLSCPVCCRAFDgaerrPTSLGCGHTLCGRCLGQLqrrlCPFDQ 54
gi 585660951   11 FLLCPICYNDFDdnvrlPISLVCGHTVCRTCLAQLhrkqCPFDQ 54
gi 321478015   11 FLSCPICRHEFDrvqrqPISLACGHTLCKTCLSKLhrrqCPFDQ 54
gi 919073701   11 FLTCPVCFNDFNgrnniPVSLGCGHTICRTCLKQLhqnkCPFEQ 54
gi 443687451   11 FLVCPICTHSFDgsalkPISLACSHTFCKACLLKLqh-kCPFDQ 53
gi 828216845   11 FKLCPVCQNEFKsglkpPISLGCGHSICKSCLLRLskqqCPFDQ 54
gi 780185950   11 VLSCPVCCKDFSpsgrqPVSLSCGHTACRMCLSKLhrqqCPFDQ 54

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