3KNV


Conserved Protein Domain Family
RING-HC_TRAF2

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cd16639: RING-HC_TRAF2 
Click on image for an interactive view with Cn3D
RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins
TRAF2, also known as tumor necrosis factor type 2 receptor-associated protein 3, is an E3 ubiquitin-protein ligase that was identified as a 75 kDa tumor necrosis factor receptor (TNF-R2)-assciated signaling protein. It interacts with members of the TNF receptor superfamily and connects the receptors to downstream signaling proteins. It also mediates K63-linked polyubiquitination of RIP1, a kinase pivotal in TNFalpha-induced NF-kappaB activation. Moreover, TRAF2 regulates peripheral CD8(+) T-cell and NKT-cell homeostasis by modulating sensitivity to IL-15. It also acts an important biological suppressor of necroptosis. It inhibits TNF-related apoptosis inducing ligand (TRAIL)- and CD95L-induced apoptosis and necroptosis. TRAF2 contains an N-terminal domain with a typical C3HC4-type RING-HC finger and several zinc fingers, and a C-terminal TRAF domain that comprises a coiled coil domain and a conserved TRAF-C domain.
Statistics
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PSSM-Id: 319553
View PSSM: cd16639
Aligned: 8 rows
Threshold Bit Score: 69.8549
Threshold Setting Gi: 190358578
Created: 3-May-2013
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding siteRING-HC finger
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
Feature 1          #  #           # #  #  #            #  # 
3KNV_A        32 YLCSACRNVLRRPFQAQCGHRYCSFCLASILSsgp-qnCAACV 73
gi 147905244  37 YLCSDCKNLLRRPLQAQCGHRYCSHCFSKIISsgp-qkCAACI 78
gi 678606077  32 YLCSDCRNILRRPFQAQCGHRYCSYCLKKIISsgp-qkCASCI 73
gi 557013041  32 YLCCDCKNILRKPYQAQCGHRYCSYCLKGLLRsgp-qdCAECL 73
gi 632964469  37 YLCVECHGILRKPFQVQCGHRFCASCLKWIVSssp-qkCAACI 78
gi 23503103   32 YLCSACRNVLRRPFQAQCGHRYCSFCLASILSsgp-qnCAACV 73
gi 190358578  40 YLCSNCNNVLNKARQTVCGHRYCLACVNWLVRnnkdlvCTKCK 82
gi 229277721  61 YLCSACRLVLREPFQTYCGHRYCKSCLDEIFRlpgiqmCKQCP 103

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