3HCS,2JMD,3HCT,2ECI


Conserved Protein Domain Family
mRING-HC-C3HC3D_TRAF6

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cd16643: mRING-HC-C3HC3D_TRAF6 
Click on image for an interactive view with Cn3D
Modified RING finger, HC subclass (C3HC3D-type), found in tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) and similar proteins
TRAF6, also known as interleukin-1 signal transducer or RING finger protein 85 (RNF85), is a cytoplasmic adapter protein that mediates signals induced by the tumor necrosis factor receptor (TNFR) superfamily and Toll-like receptor (TLR)/interleukin-1 receptor (IL-1R) family. It functions as a mediator involved in the activation of mitogen-activated protein kinase (MAPK), phosphoinositide 3-kinase (PI3K), and interferon regulatory factor pathways, as well as in IL-1R-mediated activation of NF-kappaB. TRAF6 is also an oncogene that plays a vital role in K-RAS-mediated oncogenesis. TRAF6 contains an N-terminal domain with a modified C3HC3D-type RING-HC finger and several zinc fingers, and a C-terminal TRAF domain that comprises a coiled coil domain and a conserved TRAF-C domain.
Statistics
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PSSM-Id: 319557
View PSSM: cd16643
Aligned: 19 rows
Threshold Bit Score: 99.3695
Threshold Setting Gi: 675886174
Created: 3-May-2013
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Structure:2JMD; Homo sapiens TRAF6 binds two Zn2+ ions through its modified RING-HC finger, contacts at 4A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
Feature 1           #  #            # #  #  #             #  #                
3HCS_A        18 KYECPICLMALREa-VQTPCGHRFCKACIIKSIRDAg--hKCPVDNeiLLENQLFPDNFAK 75
2JMD_A         6 KYECPICLMALREa-VQTPCGHRFCKACIIKSIRDAg--hKCPVDNeiLLENQLFPDNFAK 63
gi 118344312  43 KYMCPICLLALRDp-VQTECGHRFCHLCILRCIRSKa---SCPVDQitLFSNQLFQDRSAH 99
gi 156225095  15 SFECPVCLMALRDpvQVTPCGHRVCQTCIKPIIRNRr--pRCPLDNltLNVGKIFPDNACH 73
gi 288559206  68 KYECPICLMGLRSa-VQTPCGHRFCDSCIRKSIRDTg--qKCPVDNevLLEEQLFPDNFAK 125
gi 558651250  35 KYECPICLMCLRDp-WQTGCGHRFCKSCIQRSLREAg--pRCPVDNapLTEQTMFPDQFAK 92
gi 632973166  58 KYECPICLMALREa-VQTPCGHRFCRGCIVKSIRDAg--qKCPVDNemLLETQLFPDNFAK 115
gi 585658642  21 KYECPICLMALREp-TQTQCGHRFCRSCICQSMRETg--sKCPIDNtpLSFSSLFPDNFAK 78
gi 85687488   90 KYDCPICLLVLRDp-YQTECGHRFCQNCIKRWLRETesepRCPVDNapLGEGQIFPDNFAK 149
gi 919040134  97 KYECPICLMCLRDp-YQTYCGHRFCKYCIFKWLREEk--hRCPVDNvlLDEQNIYPDNFAK 154

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