Conserved Protein Domain Family
mRING-HC-C3HC5_MAPL

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cd16648: mRING-HC-C3HC5_MAPL 
Modified RING finger, HC subclass (C3HC5-type), found in mitochondrial-anchored protein ligase (MAPL) and similar proteins
MAPL, also known as MULAN, mitochondrial ubiquitin ligase activator of NFKB 1, E3 SUMO-protein ligase MUL1, E3 ubiquitin-protein ligase MUL1, growth inhibition and death E3 ligase (GIDE), putative NF-kappa-B-activating protein 266, or RING finger protein 218 (RNF218), is a multifunctional mitochondrial outer membrane protein involved in several processes specific to metazoan (multicellular animal) cells, such as NF-kappaB activation, innate immunity and antiviral signaling, suppression of PINK1/parkin defects, mitophagy in skeletal muscle, and caspase-dependent apoptosis. MAPL contains a unique BAM (beside a membrane)/GIDE (growth inhibition death E3 ligase) domain and a C-terminal modified cytosolic C3HC5-type RING-HC finger which is distinguished from typical C3HC4-type RING-HC finger due to the existence of the additional cysteine residue in the middle portion of the RING finger domain.
Statistics
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PSSM-Id: 319562
View PSSM: cd16648
Aligned: 12 rows
Threshold Bit Score: 70.516
Threshold Setting Gi: 765549865
Created: 3-May-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding sitemodified
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens Parkin (5C1Z) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
Feature 1         #  #           # #   #  #         #  # 
gi 74760689  301 ACVVCLSsfKSCVFLECGHVCSCTECYRALpepkkCPICR 340
gi 82202144  302 PCSICLSteKSCVFLECGHVCSCISCYQALpspkkCPICR 341
gi 82232105  291 ACVICLSnpRGCVLLDCGHVCCCFRCYQALpq-pfCPICR 329
gi 632967930 302 ACSICLAseRSCVFLECGHVCSCHECYRALpspkkCPICR 341
gi 556954046 301 ACVICLStaRSCVFLECGHVCSCDECYQALlapkkCPICR 340
gi 677158298 234 ACVICLSdtKSCVFLECGHVCSCNDCYRALpepkrCPICR 273
gi 156379438 294 QCVICLEnqRNVVLLNCGHVCSCRTCAQQIh---qCPVCR 330
gi 291227838 293 VCVICLNnpREVVILNCGHICACAECATALqp-pqCPICR 331
gi 72034521  293 SCAICLSrpRDCVLLNCGHVCACSECAIVLqp-pqCPICR 331
gi 198432867 309 SCVVCLTnpRECILLDCGHICVCIDCLEALpspkqCPVCR 348
gi 765549865 316 LCVVCLDheRNAVLLECGHRCACMTCARELr---aCPICR 352
gi 443728684 380 SCVVCLAnpRELIVLECGHLCLCGDCARELpqprrCPICR 419

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