2C2V,2C2L,2F42,2OXQ,4WZ0,4WZ3


Conserved Protein Domain Family
RING-Ubox_CHIP

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cd16654: RING-Ubox_CHIP 
Click on image for an interactive view with Cn3D
U-box domain, a modified RING finger, found in carboxyl terminus of HSP70-interacting protein (CHIP) and similar proteins
CHIP, also known as STIP1 homology and U box-containing protein 1 (STUB1), CLL-associated antigen KW-8, or Antigen NY-CO-7, is a multifunctional protein that functions both as a co-chaperone and an E3 ubiquitin-protein ligase. It couples protein folding and proteasome mediated degradation by interacting with heat shock proteins (e.g. HSC70) and ubiquitinating their misfolded client proteins thereby targeting them for proteasomal degradation. It is also important for cellular differentiation and survival (apoptosis), as well as susceptibility to stress. It targets a wide range of proteins, such as expanded ataxin-1, ataxin-3, huntingtin, and androgen receptor, which play roles in glucocorticoid response, tau degradation, and both p53 and cAMP signaling. CHIP contains an N-terminal tetratricopeptide repeat (TPR) domain responsible for protein-protein interaction, a highly charged middle coiled-coil (CC), and a C-terminal RING-like U-box domain acting as an ubiquitin ligase.
Statistics
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PSSM-Id: 319568
View PSSM: cd16654
Aligned: 36 rows
Threshold Bit Score: 85.7598
Threshold Setting Gi: 747155568
Created: 14-Apr-2015
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 26 residues -Click on image for an interactive view with Cn3D
Feature 1:polypeptide substrate binding site 1 [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
Feature 1         # ##   ## #        ## # #       ##  ##    ## #         ### ### ##  # 
2C2V_S          2 IPDYLCGKISFELMREPCITPSGITYDRKDIEEHLqRVGHFNPVTRSplt-qeQLIPN-LAMKEVIDAF 68
4WZ0_A         23 TPTXLTXPIDSGFLKDPVITPEGFVYNKSSILKWL-ETKKEDPQSRKplt-akDLQPF-PELLIIVNRF 88
4WZ3_B         31 TPTXLTCPIDSGFLKDPVITPEGFVYNKSSILKWL-ETKKEDPQSRKplt-akDLQPF-PELLIIVNRF 96
gi 75337574   200 VPDYLCCNITLEIFRDPVISPSGVTYERAAILEHLkKVGKFDPITREkid-paNLVPN-LAIKEAVAAY 266
gi 159478583  196 APSQFTCPLTMEIFRDPVVAPSGRSYERTALLEHLkKVGKFDPITRQpiageeALVPN-VSLRAAIELY 263
gi 162665803  200 VPDYLCCQISMDIFRDPVITPSGVTYERSILLEHLcKVGKFDPITRAtlh-peQVAPN-LAVKDAVQTF 266
gi 294461731  243 VPEYLCCKITLDIFRDPVITPSGVTYERAVILEHIrKVGNFDPITREplk-peQLVPN-LAIKEAVQDF 309
gi 300171062  203 IPEHLCCKITMDVFRDPVITPSGVSYERAVLLEHLrKVGKFDPWTRAple-peQIVSN-LALKEAVQAY 269
gi 354547778  159 APDYLLDPISFEILTDPVVTPSGITYEKEEILNHInNKGKYDPISKQpls-kdQLYPN-LIIKDTVEAY 225
gi 585668218  961 LPSHLICPLTKELFVDPVVTPYGHVYERHAIEDHL-SKSNYDPMAKKplq-rgQLKPKnGIFKLVTEYR 1027

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