Conserved Protein Domain Family
RING-Ubox_WDSUB1_like

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cd16655: RING-Ubox_WDSUB1_like 
U-box domain, a modified RING finger, found in WD repeat, SAM and U-box domain-containing protein 1 (WDSUB1) and similar proteins
WDSUB1 is an uncharacterized protein containing seven WD40 repeats and a SAM domain in addition of the U-box. Its biological role remains unclear. The family also includes many uncharacterized kinase domain-containing U-box (AtPUB) proteins and several MIF4G motif-containing AtPUB proteins from Arabidopsis.
Statistics
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PSSM-Id: 319569
View PSSM: cd16655
Aligned: 40 rows
Threshold Bit Score: 69.1699
Threshold Setting Gi: 397643006
Created: 14-Apr-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
U-box domain, a
Feature 1:U-box domain, a modified RING finger [structural motif]
Evidence:
  • Comment:The U-box is a modified form of the RING finger domain that lacks metal chelating cysteines and histidines. Like the RING finger, the U-box is thought to form a structure consisting of three beta-sheets and a single alpha-helix, which would be stabilized by salt bridges instead of chelated metal ions.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
Feature 1           #  #           # #  #  #                          #  # 
gi 229463016  408 FICPITRELMKDPviasDGYSYEKEAMENWIskk---------------krtSPMTN 449
gi 340373787  395 LRCPITQDIFQDPvvaaDGHTYERSAMMSWLmeg---------------krsSPVTN 436
gi 955172443  294 FVCPLTHELFEQPvvaaDGHTYEASYMIQWLtmr----------------dtSPTCG 334
gi 662521633  599 LRCPIKLDLIEDPvvaaDGQTYGRQAMVKWMsir----------------rsSPLTG 639
gi 970663476  485 LICPITGCPMVDPvvaaDGHSYEREAIMQWFtts----------------diSPMTG 525
gi 397643006  180 FLCPIQNTLLVDPvidgEGHTYERDAILRWLvltnrltavvgvagddsscgtSPITG 236
gi 294867762  321 FMCPITRAPLRCPavacDGHTYERGAIHRWLarn----------------dkSPVTG 361
gi 75116874   329 FICPISLEVMKDPqlaaDGFTYEAEAISTWLqgg---------------hetSPMTN 370
gi 75151267   298 FICPISKDIMQNPhvaaDGYTYEADEFRRWLnhg---------------gekSPMTN 339
gi 75180094   237 FKCPISMEIMRDPhvaaDGFTYEAEEFRKWLrsg---------------grtSPKTN 278

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