Conserved Protein Domain Family
RING-H2_RNF43_like

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cd16666: RING-H2_RNF43_like 
RING finger, H2 subclass, found in RING finger proteins RNF43, ZNRF3, and similar proteins
RNF43 and ZNRF3 (also known as RNF203) are transmembrane E3 ubiquitin-protein ligases that belong to the PA-TM-RING ubiquitin ligases family, which has been characterized by containing an N-terminal signal peptide, a protease-associated (PA) domain, a transmembrane (TM) domain and a C3H2C3-type RING-H2 finger domain followed by a long C-terminal region. Both RNF43 and RNF203 function as tumor suppressors involved in the regulation of Wnt/beta-catenin signaling. They negatively regulate Wnt signaling through interacting with complexes of frizzled receptors (FZD) and low-density lipoprotein receptor-related protein (LRP) 5/6, which leads to ubiquitination of Frizzled receptors (FZD) and endocytosis of the Wnt receptor. Dishevelled (DVL), a positive Wnt regulator, is required for ZNRF3/RNF43-mediated ubiquitination and degradation of FZD. They also associate with R-spondin 1 (RSPO1). This interaction may block Frizzled ubiquitination and enhances Wnt signaling.
Statistics
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PSSM-Id: 319580
View PSSM: cd16666
Aligned: 9 rows
Threshold Bit Score: 95.2005
Threshold Setting Gi: 126253847
Created: 18-Mar-2016
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-H2 finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Mus musculus RNF126 (2ECT) binds two Zn2+ ions through its RING-H2 finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
Feature 1         #  #              # #  #  #          #  #   
gi 74757361  271 VCAICLEEFsEGQELRVISCLHEFHRNCVDPWLhqhRTCPLCMFN 315
gi 74096373  253 LCAICLEVFnENEELRVIPCSHEFHKHCVDPWLkekLTCPLCNFN 297
gi 71994179  316 RCVICLEEYeEGTELRVLFCGHEFHPKCVDPWLlskRRCPLCQFD 360
gi 126253847 292 DCAICLEKYiDGEELRVIPCTHRFHRKCVDPWLlqhHTCPHCRHN 336
gi 291221742 264 ICAICLEQFkDGDELRVVSCSHEFHRHCVDPWLiknRTCPLCLHN 308
gi 390352280  79 ICAICLEEFrEGEEVRIVPCAHEFHKHCVDPWLlsnRTCPLCMFN 123
gi 512821131 267 VCAICLEEFtDGQELRILPCCHEYHLGCVDPWLrqnHTCPLCMYD 311
gi 918305014 187 ACAICLEDYrNGQELRVLPCQHEFHRSCVDPWLvtnRTCPLCLHN 231
gi 919052080 280 QCAICLEEYkDGQVLRLLPCNHEFHKACVDPWLlvnHTCPLCLFD 324

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