2ECT


Conserved Protein Domain Family
RING-H2_RNF126_like

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cd16667: RING-H2_RNF126_like 
Click on image for an interactive view with Cn3D
RING finger, H2 subclass, found in RING finger proteins RNF126, RNF115, and similar proteins
The family includes RING finger proteins RNF126, RNF115, and similar proteins. RNF126 is a Bag6-dependent E3 ubiquitin ligase that is involved in the mislocalized protein (MLP) pathway of quality control. It regulates the retrograde sorting of the cation-independent mannose 6-phosphate receptor (CI-MPR). RNF126 promotes cancer cell proliferation by targeting the tumor suppressor p21 for ubiquitin-mediated degradation, and could be a novel therapeutic target in breast and prostate cancers. It is also able to ubiquitylate cytidine deaminase (AID), a poorly soluble protein that is essential for antibody diversification. RNF115, also known as Rab7-interacting ring finger protein (Rabring 7), or zinc finger protein 364 (ZNF364), or breast cancer-associated gene 2 (BCA2), is an E3 ubiquitin-protein ligase that is an endogenous inhibitor of adenosine monophosphate-activated protein kinase (AMPK) activation and its inhibition increases the efficacy of metformin in breast cancer cells. It also functions as a co-factor in the restriction imposed by tetherin on HIV-1, and targets HIV-1 Gag for lysosomal degradation, impairing virus assembly and release, in a tetherin-independent manner. Moreover, RNF115 is a Rab7-binding protein that stimulates c-Myc degradation through mono-ubiquitination of MM-1. It also plays crucial roles as a Rab7 target protein in vesicle traffic to late endosome/lysosome and lysosome biogenesis. RNF115 and RNF126 associate with the epidermal growth factor receptor (EGFR) and promote ubiquitylation of EGFR, suggesting they play a role in the ubiquitin-dependent sorting and downregulation of membrane receptors. Both of them contain an N-terminal BCA2 Zinc-finger domain (BZF), the AKT-phosphorylation sites, and the C-terminal C3H2C3-type RING-H2 finger.
Statistics
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PSSM-Id: 319581
View PSSM: cd16667
Aligned: 18 rows
Threshold Bit Score: 83.136
Threshold Setting Gi: 302773077
Created: 2-May-2013
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding siteRING-H2 finger
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Structure:2ECT; Mus musculus RNF126 binds two Zn2+ ions through its RING-H2 finger.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
Feature 1          #  #                  # #  #  #          #  # 
2ECT_A         17 ECPVCKEDYal----gESVRQLPCNHLFHDSCIVPWLEqHDSCPVCR 59
gi 569403560  328 TCPICKDEFar----gDKLHLLPCQHRYHCDCILPWLNqHNTCPVCR 370
gi 15224865    95 PCAICREDFvv----gESARRLPCNHLYHNDCIIPWLTsHNSCPLCR 137
gi 302773077   28 SCAVCKDDYav----gNKVRQMPCKHVYHQDCILPWLAlHGTCPVCR 70
gi 635369748  191 ECAVCKDEFnl----aEEARRMPCTHTFHPDCILPWLKqHNSCPICR 233
gi 168050235  365 QCAVCKDEFel----gALVRQMPCKHMYHADCILPWLAqHNSCPVCR 407
gi 770203888  240 VCTVCQETMs-----gNGTLTLSCGHVFHNDCVVPWLEqRRTCPLCR 281
gi 403368233  407 LCTICQENLpi----gEKAMIIPCGHIFHPDCVLPWLKdHNTCPVCR 449
gi 583215360  360 SCAICREEYkendevhRITDNERCRHVFHCSCIIPWLKeRNSCPTCR 406
gi 633908756  147 PCTVCHDTLgv----gDVVMELPCNHCFHPDCIMPWLEsHNTCPICR 189

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