Conserved Protein Domain Family
RING-H2_RNF181

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cd16669: RING-H2_RNF181 
RING finger, H2 subclass, found in RING finger protein 181 (RNF181) and similar proteins
RNF181, also known as HSPC238, is a platelet E3 ubiquitin-protein ligase containing a C3H2C3-type RING-H2 finger. It interacts with the KVGFFKR motif of platelet integrin alpha(IIb)beta3, suggesting a role for RNF181-mediated ubiquitination in integrin and platelet signaling. It also suppresses the tumorigenesis of hepatocellular carcinoma (HCC) through the inhibition of extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) signaling in the liver.
Statistics
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PSSM-Id: 319583
View PSSM: cd16669
Aligned: 17 rows
Threshold Bit Score: 78.9517
Threshold Setting Gi: 428185968
Created: 2-May-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-H2 finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Mus musculus RNF126 (2ECT) binds two Zn2+ ions through its RING-H2 finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
Feature 1         #  #                # #  #  #          #  #    
gi 74761852   75 KCPVCLLEFEEee--taIEMPCHHLFHSSCILPWLsKTNSCPLCRYEL 120
gi 291243917  82 KCPVCLLEFDIhe--kaKQLPCQHQFHSGCILPWLkKTNSCPVCRHEL 127
gi 524903894  78 KCPICLLEFDEed--evKIMPCGHQFHSGCILPWLsKVNSCPMCRYEL 123
gi 342326454  77 QCPVCLKEWTEge--emKELPCKHSLHSSCILPWLkKTNSCPMCRHEL 122
gi 229272225  80 SCPVCLAEFDEye--fvKVMPCQHKFHPSCILPWLsKTNSCPVCRHEL 125
gi 390367578  75 KCPICLLPYRRgd--vtKTLPCTHEFHQTCILPWLgKTNSCPLCRHEL 120
gi 198431560  65 KCPVCLVPYSGt----vIEMPCNHSFHKDCLHPWLnKTNSCPVCRFEL 108
gi 734545685 883 LCPVCICEWERdesvrlVRMPCGHILHERCILPWLkRTNSCPVCRHEL 930
gi 221132401  60 SCPICLKVFEEksl-vkELPKCKHSFHATCILPWLyKTNTCPMCRYEY 106
gi 919094225  73 KCPICLVPYDEae--atKQLPCQHKFHPECILPWLqKTNSCPVCRYEL 118

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