Conserved Protein Domain Family
RING-H2_RNF215

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cd16670: RING-H2_RNF215 
RING finger, H2 subclass, found in RING finger protein 215 (RNF215) and similar proteins
This family includes uncharacterized protein RNF215 and similar proteins. Although its biological function remains unclear, RNF215 shares high sequence similarity with PA-TM-RING ubiquitin ligases, which have been characterized by containing an N-terminal signal peptide, a protease-associated (PA) domain, a transmembrane (TM) domain and a C-terminal C3H2C3-type RING-H2 finger domain.
Statistics
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PSSM-Id: 319584
View PSSM: cd16670
Aligned: 5 rows
Threshold Bit Score: 106.52
Threshold Setting Gi: 632968323
Created: 2-May-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
Conserved Features/SitesClick to see Conserved Features Help
 
Zn binding siteRING-H2 finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Mus musculus RNF126 (2ECT) binds two Zn2+ ions through its RING-H2 finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
Feature 1          #  #              # #  #  #          #  #       
gi 147732500 323 ETCAVCLDYFcnKQWLRVLPCKHEFHRDCVDPWLMLQQTCPLCKFNVLGN 372
gi 557020741 319 ESCAVCLDHFhkNQCLRVLPCLHEFHRDCVDPWLLLQQTCPLCKRNILGN 368
gi 528478717 300 ESCAVCLEQYnnNQCLRVLPCLHEFHRDCVDPWLLLQQTCPLCKRSVLGN 349
gi 543723570 299 DSCAVCLDQFhkSQWLRVLPCSHEFHRDCVDPWLLLQQTCPLCKRNILGN 348
gi 632968323 179 ENCAVCLEEFykNQCLRVLPCLHEFHRDCVDRWLLLQQTCPLCKRNVLDD 228

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