Conserved Protein Domain Family
RING-H2_RNF215
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cd16670: RING-H2_RNF215 
RING finger, H2 subclass, found in RING finger protein 215 (RNF215) and similar proteins
This family includes uncharacterized protein RNF215 and similar proteins. Although its biological function remains unclear, RNF215 shares high sequence similarity with PA-TM-RING ubiquitin ligases, which have been characterized by containing an N-terminal signal peptide, a protease-associated (PA) domain, a transmembrane (TM) domain and a C-terminal C3H2C3-type RING-H2 finger.
Links
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Statistics
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PSSM-Id: 438332
Aligned: 7 rows
Threshold Bit Score: 95.2137
Created: 2-May-2013
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Conserved Features/SitesClick to see Conserved Features Help
 
Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H H C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-H2 fingers with bound zinc
  • Comment:C3H2C3-type RING-H2 finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-H-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #              # #  #  #          #  #       
Q9Y6U7       323 ETCAVCLDYFcNKQWLRVLPCKHEFHRDCVDPWLMLQQTCPLCKFNVLGN 372 human
XP_006010686 319 ESCAVCLDHFhKNQCLRVLPCLHEFHRDCVDPWLLLQQTCPLCKRNILGN 368 coelacanth
XP_005165127 300 ESCAVCLEQYnNNQCLRVLPCLHEFHRDCVDPWLLLQQTCPLCKRSVLGN 349 zebrafish
XP_007900463 179 ENCAVCLEEFyKNQCLRVLPCLHEFHRDCVDRWLLLQQTCPLCKRNVLDD 228 elephant shark
XP_415299    306 DSCAVCLDQFsKSQWLRVLPCSHEFHRDCVDPWLLLQQTCPLCKHNILGN 355 chicken
XP_002128365 314 ERCAICLDKYySLQRLRVLPCKHRFHVGCIDPWLLTRRTCPLCKFDILGN 363 vase tunicate
ELU07806     216 DTCAICLDLYkPKQRLRILPCGHEFHASCVDPWLLSQQTCPLCKCNAIDE 265 Capitella teleta

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