1V87


Conserved Protein Domain Family
RING-H2_DTX2

?
cd16672: RING-H2_DTX2 
Click on image for an interactive view with Cn3D
RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
DTX2, also known as RING finger protein 58, together with DTX1 and DTX4, forms a family of related proteins that are the mammalian homologs of Drosophila Deltex, a known regulator of Notch signals. Like DTX1 and DTX4, DTX2 is expressed in thymocytes. It interacts with the intracellular domain of Notch receptors and acts as a negative regulator of Notch signals in T cells. However, the endogenous levels of DTX1 and DTX2 is not important for regulating Notch signals during thymocyte development. DTX2 contains N-terminal two Notch-binding WWE domains that physically interact with the Notch ankyrin domains, a proline-rich motif that shares homology with SH3-binding domains, and a C3H2C3-type RING-H2 finger at the C-terminus. It also harbors two nuclear localization signals.
Statistics
?
PSSM-Id: 319586
View PSSM: cd16672
Aligned: 6 rows
Threshold Bit Score: 139.589
Threshold Setting Gi: 159163211
Created: 19-Mar-2015
Updated: 18-Aug-2016
Structure
?
Program:
Drawing:
Aligned Rows:
 
Zn binding siteRING-H2 finger
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Structure:1V87; Mus musculus Deltex2 binding two Zn2+ ions through its RING-H2 finger.
    View structure with Cn3D

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
Feature 1         #  #                              # #  #  #               #  #          
1V87_A        27 DCIICMEKLAvaSGYSdmtdsk-algpmvVGRLTKCSHAFHLLCLLAMYcNGNKDGSLQCPSCKTIYGEKTGT 98
gi 148224562 334 DCIICMEPLNiaSGYSdavesk-nikptaVGKLKKCAHTFHQLCMLAMYnNGNKDGSLQCPACKTIYGEKTGT 405
gi 556947937 404 SCIICMEKLScaSGYDemsksn-tmqasaVGKLTKCGHVFHLLCMLAMYnNGNKDGSLQCPSCKAIYGEKTGT 475
gi 632958130 365 DCIICMEKLSdlSGYDgvshsk-tiqpdsVGKFTKCGHIFHLLCMMAMYeNGTKDGSLQCPSCKMIYGEKTGT 436
gi 190339820 348 DCIICMERLScpSGYEvpaecsqslqpstVGKLTKCAHTFHMLCMLAMYnNGTKDGSLQCPSCKTIYGEKTGT 420
gi 679196996 390 DCIICMEKLSspSGYSdtcess-tirpeaVGRLTSCQHSFHMLCMLAMYsNGNKDGSLQCPSCKTIYGEKTGT 461

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap