Conserved Protein Domain Family
RING-H2_RNF6

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cd16673: RING-H2_RNF6 
RING finger, H2 subclass, found in E3 ubiquitin-protein ligase RNF6 and similar proteins
RNF6 is an androgen receptor (AR)-associated protein that induces AR ubiquitination and promotes AR transcriptional activity. RNF6-induced ubiquitination may regulate AR transcriptional activity and specificity through modulating cofactor recruitment. RNF6 is overexpressed in hormone-refractory human prostate cancer tissues and required for prostate cancer cell growth under androgen-depleted conditions. Moreover, RNF6 regulates local serine/threonine kinase LIM kinase 1 (LIMK1) levels in axonal growth cones. RNF6-induced LIMK1 polyubiquitination is mediated via K48 of ubiquitin and leads to proteasomal degradation of the kinase. RNF6 also binds and upregulates the Inha promoter, and functions as a transcription regulatory protein in the mouse sertoli cell. Furthermore, RNF6 acts as a potential tumor suppressor gene involved in the pathogenesis of esophageal squamous cell carcinoma (ESCC). RNF6 contains an N-terminal coiled-coil domain, a Lys-X-X-Leu/Ile-X-X-Leu/Ile (KIL) motif, and a C-terminal C3H2C3-type RING-H2 finger which is responsible for its ubiquitin ligase activity. The KIL motif is present in a subset of RING-H2 proteins from organisms as evolutionarily diverse as human, mouse, chicken, Drosophila, Caenorhabditis elegans, and Arabidopsis thaliana.
Statistics
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PSSM-Id: 319587
View PSSM: cd16673
Aligned: 5 rows
Threshold Bit Score: 110.115
Threshold Setting Gi: 556960029
Created: 6-May-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-H2 finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens RNF38 (4V3K) binds two Zn2+ ions through its RING-H2 finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
Feature 1          #  #              # #  #  #          #  #  
gi 13124536  630 KICSVCISDYvtGNKLRQLPCMHEFHIHCIDRWLSENcTCPICRQ 674
gi 195539967 659 RACSVCINEYaqGNKLRRLPCAHEFHIHCIDRWLSENnTCPICRQ 703
gi 632965293 656 KTCSVCINEYavGNKLRRLPCAHEFHIHCIDRWLSENsTCPICRQ 700
gi 556960029 653 KTCSVCINEYaaGNKLKRLPCAHEFHIHCIDRWLSENsTCPICRQ 697
gi 465983755 633 KTCSVCINEYvtGNKLRQLPCMHEFHIHCIDRWLSENsTCPICRQ 677

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