Conserved Protein Domain Family
RING-H2_RNF32_rpt2
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cd16678: RING-H2_RNF32_rpt2 
second RING finger, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
RNF32 is mainly expressed in testis spermatogenesis, most likely in spermatocytes and/or in spermatids, suggesting a possible role in sperm formation. RNF32 contains two C3H2C3-type RING-H2 fingers separated by an IQ domain of unknown function. Although the biological function of RNF32 remains unclear, proteins with double RING-H2 fingers may act as scaffolds for binding several proteins that function in the same pathway. This model corresponds to the second RING-H2 finger.
Links
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Statistics
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PSSM-Id: 438340
Aligned: 20 rows
Threshold Bit Score: 76.6381
Created: 27-Jul-2013
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H H C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-H2 fingers with bound zinc
  • Comment:C3H2C3-type RING-H2 finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-H-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #  #                                # #  #  #                 #  #    
Q9H0A6       292 ECSICLAPLsaaggqrvg-------agrrsremALLSCSHVFHHACLLALEEFsvgdrppfhaCPLCRSCY 355 human
EEY61294     150 ECAICINGFsssm-----------------egvLLLSCSHAFHSQCLSAFEDFsiye---vslCPVCRASY 200 Phytophthora infestans T...
CAK61421     265 DCTICLQSMvna-------------------kvFLLSCSHMFHANCLNSFERYsmtq---vnnCPICRQTY 313 Paramecium tetraurelia s...
XP_005840381 293 DCAICLCDLggps-----------------kkkVLTSCSHLFHANCLESFERFssamaevdslCPCCRSKY 346 Guillardia theta CCMP2712
XP_014347580 323 DCPICITPLhysnnsfsate--dksshhssrqiVLLSCSHVFHNTCLHAFEEFsvee---tpvCPLCRSLY 388 coelacanth
XP_001233776 298 DCPICIMPLsptahpac---------npfspqtVLLSCSHLFHHTCLEAFEEFslgl---qhiCPLCRSYY 356 chicken
XP_024534883 202 DCSICIMPLqkdg----------------gsnlSLLSCSHLFHSHCISEFEAFhasa---ellCPICRTMY 253 Selaginella moellendorffii
XP_012563760 279 HCSICLTKLkkg-------------------nnTLLSCSHLFHTACLNSYEFYceni---elvCPICRSSY 327 swiftwater hydra
XP_003061056 385 DCPICFAALrrsreeddagdggdarhrvdaaplALLDCSHCFHMKCLRAFEAYnsavg-rartCPICRGEY 454 Micromonas pusilla CCMP1545
PNW78548     389 DCPICLGHIsrrg----------------negiAWLSCTHCFHIDCIMAFEAFelasg-gtpsCPVCRSGY 442

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