Conserved Protein Domain Family
RING2-H2_RNF32

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cd16678: RING2-H2_RNF32 
RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
RNF32 is mainly expressed in testis spermatogenesis, most likely in spermatocytes and/or in spermatids, suggesting a possible role in sperm formation. RNF32 contains two C3H2C3-type RING-H2 fingers separated by an IQ domain of unknown function. Although the biological function of RNF32 remains unclear, the protein with double RING-H2 fingers may act as a scaffold for binding several proteins that function in the same pathway. This family corresponds to the second RING-H2 finger.
Statistics
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PSSM-Id: 319592
View PSSM: cd16678
Aligned: 17 rows
Threshold Bit Score: 69.3314
Threshold Setting Gi: 398023347
Created: 27-Jul-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-H2 finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens RNF25 (5D1K) binds two Zn2+ ions through its RING-H2 finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #  #                                                # #  #  #                  
gi 74717970  292 ECSICLAPLsaaggqrvg-----------------------agrrsremALLSCSHVFHHACLLALEEFsvgdr------ 342
gi 459172823 308 ECPICLRGLadcrhsnet----------------------taivknepiALLSCSHVFHATCLNALESFsmdndvtssys 365
gi 761904746 212 DCVICLAPLslp----------------------------------rplTVLSCSHLFHTTCITSLESFtsdy------- 250
gi 195999564 274 ECPICIAPIekprastsk----------------------skngnskqlVILSCSHIFHQVCLEAFEEFsiqa------- 324
gi 443704975 293 DCPICLNQLqslslieenalsndsnitrklqnklrrphgarktgvrketLLLSCSHVFHATCLEAFEDFsege------- 365
gi 116235438 287 DCPICLNHLtshngss---------------------------kenrniLLLSCSHLFHEVCLQAFELFcqev------- 332
gi 262103242 150 ECAICINGFsssm---------------------------------egvLLLSCSHAFHSQCLSAFEDFsiye------- 189
gi 290979115 271 ECPICLCAFkgr-----------------------------------kcTITSCGHIFHEKCLSSFEKFiesk------- 308
gi 124395907 265 DCTICLQSMvna-----------------------------------kvFLLSCSHMFHANCLNSFERYsmtq------- 302
gi 551675253 293 DCAICLCDLggps---------------------------------kkkVLTSCSHLFHANCLESFERFssama------ 333
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
Feature 1                                               #  #    
gi 74717970  343 ----------------------------------ppfhaCPLCRSCY 355
gi 459172823 366 hdvmtstpnvtgpssnltssnlmtlsnpdqppdiplsfkCPVCRSLY 412
gi 761904746 251 -----------------------------------tlhsCPICRSPY 262
gi 195999564 325 ------------------------------------tkvCPVCRSHY 335
gi 443704975 366 -----------------------------------krfvCPVCRSHY 377
gi 116235438 333 ------------------------------------kptCPLCRSHY 343
gi 262103242 190 ------------------------------------vslCPVCRASY 200
gi 290979115 309 ------------------------------------nqkCPVCRQIY 319
gi 124395907 303 ------------------------------------vnnCPICRQTY 313
gi 551675253 334 ----------------------------------evdslCPCCRSKY 346

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