4V3K,1X4J


Conserved Protein Domain Family
RING-H2_RNF38

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cd16679: RING-H2_RNF38 
Click on image for an interactive view with Cn3D
RING finger, H2 subclass, found in RING finger protein 38 (RNF38) and similar proteins
RNF38 is a nuclear E3 ubiquitin protein ligase that is widely expressed throughout the body in human, especially highly expressed in the heart, brain, placenta and the testis. It recognizes p53 as a substrate for ubiquitination, and thus plays a role in regulating p53. The overexpression of RNF38 increases p53 ubiquitination and alters p53 localization. It is also capable of autoubiquitination. Moreover, RNF38 expression is negatively regulated by the serotonergic system. Induction of RNF38 may be involved in the anxiety-like behavior or non-cell autonomous by the decline of serotonin (5-HT) levels. RNF38 contains a coiled-coil motif, a KIL motif (Lys-X2-Ile/Leu-X2-Ile/Leu, X can be any amino acid), and a C3H2C3-type RING-H2 finger, as well as two potential nuclear localization signals.
Statistics
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PSSM-Id: 319593
View PSSM: cd16679
Aligned: 8 rows
Threshold Bit Score: 85.1124
Threshold Setting Gi: 806394279
Created: 24-Mar-2015
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
Feature 1             #  #              # #  #  #          #  #    
4V3K_C         23 EQTLCVVCMCDFEsRQLLRVLPCNHEFHAKCVDKWLKaNRTCPICRADA 71
1X4J_A         22 EQTLCVVCMCDFEsRQLLRVLPCNHEFHAKCVDKWLKaNRTCPICRADS 70
gi 120577569  440 EQTLCVVCMCDFEsRQLLRVLPCNHEFHAKCVDKWLKaNRTCPICRADA 488
gi 260830993  966 QQTLCVVCMCDFEnRQLLRVLPCNHEFHAKCVDKWLKsNRTCPICRADA 1014
gi 292609636  617 EQTLCVVCMCDFEsRQLLRVLPCNHEFHAKCVDKWLKaNRTCPICRADA 665
gi 557015279  408 EQTLCVVCMCDFEsRQLLRVLPCNHEFHAKCVDKWLKaNRTCPICRADA 456
gi 632962272  395 EQTLCVVCMCDFEsRQLLRVLPCNHEFHAKCVDKWLKaNRTCPICRADA 443
gi 677464186  404 EQTLCVVCMCDFEsRQLLRVLPCNHEFHAKCVDKWLKaNRTCPICRADA 452

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