Conserved Protein Domain Family
RING-H2_Vps8

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cd16687: RING-H2_Vps8 
RING finger, H2 subclass, found in vacuolar protein sorting-associated protein 8 (Vps8) and similar proteins
Vps8 is the Rab-specific subunit of the endosomal tethering complex CORVET (class C core vacuole/endosome transport) that also includes Vps3 and a Class C Vps core complex composed of Vps11, Vps16, Vps18, and Vps33. CORVET operates at endosomes, controls traffic into late endosomes, and interacts with the Rab5/Vps21-GTP form. The CORVET-specific Vps3 and Vps8 subunits belong to a class D Vps. They form a subcomplex that interact with Rab5/Vps21, and are critical for localization and function of the CORVET tethering complex on endosomes. Vps8 contains an N-terminal WD40 repeat and a C-terminal C3H2C3-type RING-H2 finger.
Statistics
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PSSM-Id: 319601
View PSSM: cd16687
Aligned: 12 rows
Threshold Bit Score: 80.1435
Threshold Setting Gi: 761903563
Created: 31-Jul-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-H2 finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Oryza sativa El5 (1IYM) binds two Zn2+ ions through its RING-H2 finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
Feature 1           #  #                                  # #  #  #                 #  # 
gi 296452997 1256 DYCSICLQQYkrrq----------------emaDEIIVFSCGHLYHSFCLQNKECtvefegqtRWTCYKCS 1310
gi 483513373 1134 DYCCICLQQYkrrq----------------etaDEIIVFSCGHLYHSLCLLSKECgvvtkglmRWMCYKCN 1188
gi 94732692    88 DHCNICLQQYkrrq----------------eseEEIVIFSCGHLYHCQCLQRKETgvlserqyPWSCYKCT 142
gi 158253673  789 DYCCVCLQQYkrrq----------------eatDEIIVFSCGHLYHSLCLLGKDCkvevggqsQWICHRCN 843
gi 632978356 1226 EHCGICLQQYkrrq----------------egtEEVIVFSCGHIYHSQCLHNKNCgvqtdgqtRWLCYKCN 1280
gi 556987737 1228 DHCSLCLQQYrrmq----------------eaaDEVIVFSCGHLYHSKCLKSKECglqtegqrGWTCYKCN 1282
gi 761903563  953 VLCCLCNRPAdset---------------pegiDDVIVFSCNHLYHSSCLGVTGAl------mGVTCFLCD 1002
gi 229271414  149 EDCGVCGQHFsit-----------------eeqDSVIVFSCGHAYHTSCLQSVGCchmiegtpHWSCSLCN 202
gi 585677935 1178 DNCHVCSKPHtdq------------------dqQSVCIFSCGHAYHTLCLLSVGSctmidgqqHWFCYQCN 1230
gi 405973145 1137 DNCSLCTKQFvnq-----------------netDTVIIFRCGHSYHKGCLQSIGSvhvidgedSWVCFLCS 1190
gi 443707429 1188 RSCNLCNKHIigggdevgcvvgfrsvmmvlifsHCTDCIRCGHGYHLTCLRSVGSralmdgeeVWLCYLCN 1258
gi 919101489 1242 GGCNLCAKLFvni-----------------tdnGAVIVFRCGHSYHAECLKSRGSfyktigqeQWTCYLCS 1295

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