Conserved Protein Domain Family
RING-CH-C4HC3_NFX1

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cd16696: RING-CH-C4HC3_NFX1 
RING-CH finger, H2 subclass (C4HC3-type), found in transcriptional repressor NF-X1 and similar proteins
NF-X1, also known as nuclear transcription factor, X box-binding protein 1, is a novel cysteine-rich sequence-specific DNA-binding protein that interacts with the conserved X-box motif of the human major histocompatibility complex (MHC) class II genes via a repeated Cys-His domain. It functions as a cytokine-inducible transcriptional repressor that plays an important role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by interferon gamma (IFN- gamma). NFX1 contains an N-terminal PAM2 motif, a C4HC3-type RING-CH finger, a Cys-rich region that harbors several NFX1-type zinc fingers, and a C-terminal R3H domain.
Statistics
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PSSM-Id: 319610
View PSSM: cd16696
Aligned: 27 rows
Threshold Bit Score: 66.1827
Threshold Setting Gi: 398018629
Created: 15-May-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-CH finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens FANCL (4CCG) binds two Zn2+ ions through its RING-CH finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
Feature 1           #  #            #  #    #  #                                #  # 
gi 189047116  356 YECMVCCElvrvtapVWSCQSCYHVFHLnCIKKWARSPasqad-------------gqsgWRCPACQ 409
gi 321463669   20 YECMVCCEsvkpvqpIWNCSQCFHAFHLgCVRRWSRTSqdgt--------------ksghWRCPGCQ 72
gi 545704171  141 YECMVCYEdiqrstsTWMCDTCFVVLHLsCVLKWSKSSqeqknnqqh-----hssskvahWLCPACR 202
gi 470455172  256 YECMICMNnvrrrqsIWHCEECYALFHLdCISKWSKNSleearqvpqg--ilpqkppadgWRCPHCN 320
gi 553139346  206 YECVICTNeltrntrIWSCSVCWTVTHLsCVKKWHANQeknaeqqe------qsadqplsWRCPGCN 266
gi 674218508  199 YDCVICYStvttrqaTWSCSQCYSVLHLpCVRKWADSSvkkaeehnamqedpeirnrrgtWRCPGCQ 265
gi 74996425   364 YECMVCFEnvgknavIWSCSQCFTMFHSsCIKQWSSKSvtt----------------egkWKCPGCR 414
gi 75337836   221 IECMICYDkvgrsanIWSCSSCYSIFHInCIKRWARAPtsvdlla--------eknqgdnWRCPGCQ 279
gi 302771427   19 MECMICYDmigrnarVWSCSGCYSIFHLtCIRKWARAPtsvd--------------qsgnWRCPGCQ 71
gi 168049263   51 VECMICYDnvgrnapVWSCASCYSIFHMpCIRKWVRAPtssdisvs------aagngeanWRCPGCQ 111

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