2D8S


Conserved Protein Domain Family
RING_CH-C4HC3_MARCH1_like

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cd16698: RING_CH-C4HC3_MARCH1_like 
Click on image for an interactive view with Cn3D
RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
This family includes the closely related MARCH1 and MARCH8, both of which are located on endosomes and the plasma membrane and are implicated in regulating cell surface expression of their substrates. They ubiquitylate and downregulate many targets, including major histocompatibility complex class II (MHCII), CD86, transferrin receptor, HLA-DM, and Fas from the cell surface. MARCH1 is mainly expressed in cells of the immune system, while MARCH8 is more broadly expressed. Both of them contain an N-terminal C4HC3-type RING-CH finger, also known as vRING or RINGv, a variant of C3H2C3-type RING-H2 finger, and two transmembrane domains. The cytoplasmic RING-CH domain participates in the ubiquitin transfer from the E2 to its substrate. The transmembrane domains are implicated in target recognition and dimer formation.
Statistics
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PSSM-Id: 319612
View PSSM: cd16698
Aligned: 11 rows
Threshold Bit Score: 95.2017
Threshold Setting Gi: 159163996
Created: 20-Mar-2015
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding siteRING-CH finger
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Structure:2D8S; Homo sapiens MARCH8 binds two Zn2+ ions through its RING-CH finger.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
Feature 1         #  #                # #       #  #            #  #    
2D8S_A        17 ICRICHCEgdd---esPLITPCHCTGSLHFVHQACLQQWIKSSdtRCCELCKYEF 68
gi 74762613   79 ICRICHCEgde---esPLITPCRCTGTLRFVHQSCLHQWIKSSdtRCCELCKYDF 130
gi 291226260 103 ICRICHCEgdn---efPLITPCLCAGSLKYVHQQCLQHWIKSSdtKTCELCKFEL 154
gi 115707278 146 ICRICHCEgde---emPLIYPCLCLGSLHFVHQACIQQWIKSSntKNCELCRFEF 197
gi 443705954  19 LCRICHCEaev---gaPLISPCVCAGSLKYVHQRCLQQWIKSAdtKSCELCKFDF 70
gi 669310955 116 ICRICHCEatn---daPLIAPCYCSGSLKFVHQRCLQQWIKSSqtKACEVCRFSF 167
gi 198413973 184 ACRICHCEtdn--elgPLIAPCKCKGTLEFVHQSCLQQWIKSSdyKHCELCGFHF 236
gi 21355405   42 ICRICHCEsdp---qnPLLTPCYCSGSLKYVHQACLQQWLTASetNSCELCKFPF 93
gi 405973881  65 CCRICQCEvceieddsPLIAPCLCDGSMKFVHQECLQKWIKSSdkECCELCKYEY 119
gi 215503051  30 MCRICHCEada---enPLISPCYCAGSLRFVHQACLQQWIKSSdtRCCELCKFNF 81
gi 156216944   9 ICRICHCEaep---dqPLISPCHCSGSLQYVHQTCLQRWIKSSdtKKCELCNYEF 60

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