Conserved Protein Domain Family
RING_CH-C4HC3_MARCH4_like

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cd16700: RING_CH-C4HC3_MARCH4_like 
RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH4, MARCH9, MARCH11, and similar proteins
MARCH4 and MARCH9 are closely related to each other. They downregulate major histocompatibility complex-I (MHC-I). Moreover, MARCH4 and MARCH9, but not other MARCH proteins, can associate with Mult1 and prevent Mult1 expression at the cell surface in a lysine-dependent manner that can be reversed by heat shocking the cells. MARCH11 is a transmembrane RING-finger ubiquitin ligase that is predominantly expressed in developing spermatids in a stage-specific manner and is localized to the trans-Golgi network (TGN) vesicles and multivesicular bodies (MVBs). It mediates selective protein sorting via the TGN-MVB transport pathway through its ubiquitin ligase activity. SAMT family proteins have been identified as substrates of MARCH11 in mouse spermatids, suggesting that MARCH11 plays a role in mammalian spermiogenesis. Moreover, MARCH11 functions as an E3 ubiquitin ligase that targets CD4 for ubiquitination. It also forms complexes with the adaptor protein complex-1 and with fucose-containing glycoproteins including ubiquitinated forms. All family members contain an N-terminal C4HC3-type RING-CH finger, also known as vRING or RINGv, a variant of C3H2C3-type RING-H2 finger, followed by two transmembrane regions.
Statistics
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PSSM-Id: 319614
View PSSM: cd16700
Aligned: 3 rows
Threshold Bit Score: 111.952
Threshold Setting Gi: 190359893
Created: 20-Mar-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-CH finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens MARCH8 (2D8S) binds two Zn2+ ions through its RING-CH finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
Feature 1         #  #            # #       #  #            #  #    
gi 59798475  162 LCRICFqgpeqgELLSPCRCDGSVKcTHQPCLIKWISERGcWSCELCYYKY 212
gi 190359893 169 ICKICFqgaeqgELLNPCRCDGSVRyTHQLCLLKWISERGsWTCELCCYRY 219
gi 125806915 110 GCRICFqgaeqgELLSPCRCAGSVRhAHQQCLLKWISEKGsWSCELCNYRF 160

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