Conserved Protein Domain Family
RING_CH-C4HC3_MARCH7_like

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cd16703: RING_CH-C4HC3_MARCH7_like 
RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated MARCH7, MARCH10, and similar proteins
The subfamily includes two closely related membrane-associated RING-CH proteins, MARCH7 and MARCH10, both of which are predicted to have no transmembrane spanning region, but harbor a C4HC3-type RING-CH finger, also known as vRING or RINGv, a variant of C3H2C3-type RING-H2 finger, that is responsible for E3 activity. MARCH7, also known as MARCH-VII, RNF177, or axotrophin, is a ubiquitin E3 ligase expressed in multiple types of cells and tissues, including stem cells and precursor cells, and predominantly localized on the plasma membrane, and cytoplasm. MARCH7 is involved in T cell proliferation and neuronal development. It also participates in the regulation of cytoskeleton re-organization, cellular migration and invasion, cell proliferation, and tumorigenesis in ovarian carcinoma cells. Moreover, MARCH7 modulates nuclear factor kappaB (NF-kappaB) and Wnt/beta-catenin pathways. It has been identified as an authentic target of miR-101. Furthermore, ubiquitinates tau protein in vitro impairing microtubule binding. MARCH10, also known as MARCH-X or RNF190, is a microtubule-associated E3 ubiquitin ligase of developing spermatids. It is localized to the principal piece of elongating spermatids. MARCH10 is involved in spermiogenesis by regulating the formation and maintenance of the flagella in developing spermatids.
Statistics
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PSSM-Id: 319617
View PSSM: cd16703
Aligned: 3 rows
Threshold Bit Score: 124.659
Threshold Setting Gi: 74762745
Created: 20-Mar-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-CH finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens MARCH8 (2D8S) binds two Zn2+ ions through its RING-CH finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
Feature 1            #  #              # #       #  #                    #  # 
gi 296439307 655 EGDLCRICQIaggspsNPLLEPCGCVGSLQFVHQECLKKWLKVKITSGADLgAVKTCEMCK 715
gi 74762745  548 EGDLCRICQMaaasssNLLIEPCKCTGSLQYVHQDCMKKWLQAKINSGSSLeAVTTCELCK 608
gi 847169602 546 DGDTCRICLTrgdtadNHLVSPCQCTGSLKYVHQECLKRWLISKIQSGAELdAVKTCEMCR 606

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