Conserved Protein Domain Family
RING-HC_dBre1_like

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cd16705: RING-HC_dBre1_like 
RING finger, HC subclass, found in Drosophila melanogaster Bre1 (dBre1) and similar proteins
dBre1 is the functional homolog of yeast Bre1, an E3 ubiquitin ligase required for the monoubiquitination of histone H2B and, indirectly, for H3K4 methylation. dBre1 acts as a nuclear component required cell autonomously for the expression of Notch target genes in Drosophila development. dBre1 contains a C3HC4-type RING-HC finger at its C-terminus.
Statistics
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PSSM-Id: 319619
View PSSM: cd16705
Aligned: 8 rows
Threshold Bit Score: 89.6187
Threshold Setting Gi: 802701142
Created: 23-Mar-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Saccharomyces cerevisiae Bre1 (4R7E) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
Feature 1           #  #           # #  #  #           #  # 
gi 74948427   989 LTCPSCKVkRKDAVLSKCFHVFCYDCLRTRYetRQRKCPKCN 1030
gi 321469893  903 LTCPSCKVtRKDAVLTKCFHVFCFDCLRTRYetRQRKCPKCN 944
gi 405957579  949 LTCPSCKVnKKDAVLTKCFHVFCLECLKTRYetRQRKCPKCN 990
gi 215497675  836 LTCPSCKVkRKDAVLIKCFHVFCYDCLKTRYetRQRKCPKCN 877
gi 555697492  934 LTCPSCKVkKKDAVLTKCFHVFCLECLKTRYetRQRKCPKCN 975
gi 919082015  919 LTCPSCKVkRKDAVLTKCFHVFCLECLKTRYetRQRKCPKCN 960
gi 360043439 1707 LTCPTCKInRKDAILTKCFHVFCLNCLKVRYetRNRKCPKCN 1748
gi 802701142  142 LTCPSCKVrRKDGILTKCFHVFCMDCLKTRYetRRRKCPKCN 183

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