Conserved Protein Domain Family
RING-HC_dBre1-like
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cd16705: RING-HC_dBre1-like 
RING finger, HC subclass, found in Drosophila melanogaster Bre1 (dBre1) and similar proteins
dBre1 is the functional homolog of yeast Bre1, an E3 ubiquitin ligase required for the monoubiquitination of histone H2B and, indirectly, for H3K4 methylation. dBre1 acts as a nuclear component required for the expression of Notch target genes in Drosophila development. dBre1 contains a C3HC4-type RING-HC finger at its C-terminus.
Links
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Statistics
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PSSM-Id: 438365
Aligned: 6 rows
Threshold Bit Score: 147.416
Created: 23-Mar-2015
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structure of human BRE1A with bound Zn2+ ions through its RING-HC finger
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                         #  #           # #  #  #           #  #              
Q9VRP9        975 DEVMIEEIREYKETLTCPSCKVKRKDAVLSKCFHVFCYDCLRTRYETRQRKCPKCNcaFGANDYHRLYL 1043 fruit fly
EFX80871      889 DEVLREELREYKDTLTCPSCKVTRKDAVLTKCFHVFCFDCLRTRYETRQRKCPKCNaaFGANDYHRLYL 957  common water flea
EEC07169      822 DEVLMEEIKEYKEQLTCPSCKVKRKDAVLIKCFHVFCYDCLKTRYETRQRKCPKCNapFGTNDYHRLYL 890  black-legged tick
ESO00725      920 DEVLMEEIREYKEQLTCPSCKVKKKDAVLTKCFHVFCLECLKTRYETRQRKCPKCNatFGANDYHRIYL 988  Helobdella robusta
XP_013422069  905 DAVLMEELKEYKEQLTCPSCKVKRKDAVLTKCFHVFCLECLKTRYETRQRKCPKCNagFGANDFHRIYL 973  Lingula anatina
XP_013085585  947 DEVLLEEIKEYKEQLTCPSCKVNKKDAVLTKCFHVFCLECLRTRYETRQRKCPKCNagFGANDFHRLYL 1015 Biomphalaria glabrata

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