Conserved Protein Domain Family
RING-HC_CARP2

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cd16707: RING-HC_CARP2 
RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein 2 (CARP-2) and similar proteins
CARP-2, also known as rififylin, caspase regulator CARP2, FYVE-RING finger protein Sakura (Fring), RING finger and FYVE-like domain-containing protein 1, RING finger protein 189 (RNF189), or RING finger protein 34-like, is an endosome-associated E3 ubiquitin-protein ligase that targets internalized receptor interacting kinase (RIP) for proteasome-mediated degradation. It acts as a negative regulator of tumor necrosis factor (TNF)-induced nuclear factor (NF)-kappaB activation. It also regulates the p53 signaling pathway through degrading 14-3-3 sigma and stabilizing MDM2. As a caspase regulator, CARP2 does not localize to membranes in the cell and is involved in the negative regulation of apoptosis, specifically targeting two initiator caspases, caspase 8 and caspase 10. CARP2 contains an N-terminal FYVE-like domain and a C-terminal C3HC4-type RING-HC finger domain.
Statistics
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PSSM-Id: 319621
View PSSM: cd16707
Aligned: 6 rows
Threshold Bit Score: 73.8688
Threshold Setting Gi: 147905890
Created: 22-Mar-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens Parkin (5C1Z) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
Feature 1          #  #           # #   #  #      #  #   
gi 74760639  314 NLCKICMDsPIDCVLLECGHMVTCTKCGKRMnECPICRQY 353
gi 147905890 281 HLCKVCMDsPIDCVLLECGHMVTCTKCGKRMsECPICRQY 320
gi 71897079  311 NLCKICMDlPIDCVLLECGHMVTCTKCGKRMsECPICRQY 350
gi 47086243  297 NLCKICMDsPIDCVLLECGHMVTCTKCGKRMsECPICRQY 336
gi 556953677 312 NLCKICMDlPIDCVLLECGHMVTCTKCGKRMsECPICRQY 351
gi 632975663 265 NICKICMDsPIDCVLLECGHMVTCTKCGKRMsECPICRQF 304

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