Conserved Protein Domain Family
RING-HC_DTX3L

?
cd16712: RING-HC_DTX3L 
RING finger, HC subclass, found in protein Deltex-3-like (DTX3L) and similar proteins
DTX3L, also known as B-lymphoma- and BAL-associated protein (BBAP) or Rhysin-2 (Rhysin2), is a RING-domain E3 ubiquitin-protein ligase that regulates endosomal sorting of the G protein-coupled receptor CXCR4 from endosomes to lysosomes. It also regulates subcellular localization of its partner protein, B aggressive lymphoma (BAL), by a dynamic nucleocytoplasmic trafficking mechanism. DTX3L has a unique N-terminus, but lacks the highly basic N-terminal motif and the central proline-rich motif present in other Deltex (DTX) family members, such as DTX1, DTX2, and DTX4. Moreover, its C-terminal region is highly homologous to DTX3. It includes a C3HC4-type RING-HC finger, and a previously unidentified C-terminal domain. DTX3L can associate with DTX1 through its unique N-terminus and further enhance self-ubiquitination.
Statistics
?
PSSM-Id: 319626
View PSSM: cd16712
Aligned: 7 rows
Threshold Bit Score: 75.9499
Threshold Setting Gi: 260810364
Created: 10-Dec-2015
Updated: 18-Aug-2016
Structure
?
Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens RING1B (4R8P) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
Feature 1          #  #             # #  #  #           #  # 
gi 37077418   560 ICVICMDtis-nkKVLPKCKHEFCAPCINKAMSy-KPICPTCQ 600
gi 919006508 1158 NCAICMCdkd-npKTLPICKHSFCTSCIDEYFKcgKPVCPVCG 1199
gi 405955155 1077 TCVVCMDtemedpVMLKKCHHQFCRNCIEDYFSh-KPICPVCN 1118
gi 291244940 1104 ECPICMErvs-dpKMLQDCQHTFCRACIDRALKd-KPVCPVCG 1144
gi 565323185  691 CCPICLNkiy-qkKVLPKCKHAFCEACIGTAMNy-KPVCPVCN 731
gi 512883859  545 KCPICMCepk-pkLVLEKCKHVICAGCWEETKKh-KPVCPVCN 585
gi 260810364    3 DCPICMDkvv-rpKRLGCCNNVFCTDCIDKAFQv-KPVCPLCG 43

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap