Conserved Protein Domain Family
vRING-HC_IRF2BP2

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cd16716: vRING-HC_IRF2BP2 
variant of RING finger, HC subclass, found in interferon regulatory factor 2 (IRF2)-binding protein 2 (IRF-2BP2)
IRF-2BP2, also known as IRF-2-binding protein 2 or DIF-1, is a nuclear protein that binds to the C-terminal repression domain of IRF-2 and acts as an IRF-2-dependent transcriptional corepressor, both enhancer-activated and basal transcription. IRF-2BP2 also specifically interacts with the C-terminal domain of the nuclear factor of activated T cells NFAT1 transcription factor, and negatively regulates the NFAT1-dependent transactivation of NFAT-responsive promoters. Moreover, IRF2BP2 suppresses the transactivation activity of p53 on both Bax and p21 promoters. It also shows anti-apoptotic activity through the modulation of a death domain in NRIF3. In addition, IRF2BP2 functions as a cofactor of VGLL4 and plays a critical role controlling gene expression in skeletal, cardiac, and smooth muscle cells. It is a muscle-enriched transcription factor required to activate vascular endothelial growth factor-A (VEGF-A) expression in muscle. IRF-2BP2 contains an N-terminal C4-type zinc finger and a C-terminal C3HC4-type RING-HC finger with a partially new pattern. The zinc finger is responsible for the homo- and hetero-dimerization between different members of the IRF-2BP2 family. The RING-HC finger interacts with IRF2 and also with nuclear receptor interacting factor 3 (NRIF3).
Statistics
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PSSM-Id: 319630
View PSSM: cd16716
Aligned: 5 rows
Threshold Bit Score: 119.038
Threshold Setting Gi: 591348764
Created: 19-Mar-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding sitevariant RING-HC
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens IRF-2BPL (2CS3) binds two Zn2+ through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
Feature 1          # ##           #     #  #  #               #     #    
gi 229462882 504 LCCTLCHERLEDTHFVQCPSVPSHKFCFPCSRQSIKQQGasGEVYCPSGEKCPLVG 559
gi 82176657  454 LCCTLCHERLEDTHFVQCPSVPSHKFCFPCSRQSIKQQGssGEVYCPSGEKCPLVG 509
gi 591348764 267 LCCTLCHERLEDTHFVQCPSVPSHKFCFPCSRQSIKQQGasGEVYCPSGEKCPLVG 322
gi 82186043  408 LCCTLCHERLEDTHFVQCPSVPSHKFCFPCSRESIKQQGatGEVYCPSGEKCPLVG 463
gi 82188161  418 LCCTLCHERLEDTHFVQCPSVPSHKFCFPCSRESIKQQGatGEVYCPSGEKCPLVG 473

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