Conserved Protein Domain Family
RING-HC_MEX3A

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cd16720: RING-HC_MEX3A 
RING finger, HC subclass, found in RNA-binding protein MEX3A
MEX3A, also known as RING finger and KH domain-containing protein 4 (RKHD4), is a RNA-binding phosphoprotein that localizes in P-bodies and stress granules, which are two structures involved in the storage and turnover of mRNAs. It has been implicated in the regulation of tumorigenesis. It controls the polarity and stemness of intestinal epithelial cells through the post-transcriptional regulation of the homeobox transcription factor CDX2, which plays a crucial role in intestinal cell fate specification, both during normal development and in tumorigenic processes involving intestinal reprogramming. Moreover, it exhibits a transforming activity when overexpressed in gastric epithelial cells. MEX3A contains two K homology (KH) domains that provide RNA-binding capacity, and a C-terminal C3HC4-type RING-HC finger. Like other MEX-3 family proteins, MEX3A shuttles between the nucleus and the cytoplasm via the CRM1-dependent export pathway.
Statistics
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PSSM-Id: 319634
View PSSM: cd16720
Aligned: 6 rows
Threshold Bit Score: 96.1181
Threshold Setting Gi: 938072213
Created: 20-Mar-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Mus musculus Hakai (3VK6) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
Feature 1          #  #           # #   #  #           #  # 
gi 134034168 467 RDCMVCFESEVTAALVPCGHNLFCMECAVRICErtdPECPVCH 509
gi 556991597 422 RDCVVCFESEVTAAMVPCGHNLFCMECAIRICEreePKCPVCH 464
gi 541958237 324 RECMVCFESEVTAALVPCGHNLFCMECAVRICErtdPECPVCH 366
gi 642113099 463 RDCMTCFESKVTAALVPCGHNLFCMECAIRICElnhPECPVCH 505
gi 120577460 337 RECMVCFESEVTAALVPCGHNLFCMECAVRICErnePECPVCH 379
gi 938072213 532 KDCFVCYESEVTAALVPCGHKLFCMDCAGQICQsgePKCPVCH 574

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