Conserved Protein Domain Family
RING-HC_MEX3B

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cd16721: RING-HC_MEX3B 
RING finger, HC subclass, found in RNA-binding protein MEX3B
MEX3B, also known as RING finger and KH domain-containing protein 3 (RKHD3), or RING finger protein 195 (RNF195), is a RNA-binding phosphoprotein that localizes in P-bodies and stress granules, which are two structures involved in the storage and turnover of mRNAs. It regulates the spatial organization of the Rap1 pathway that orchestrates Sertoli cell functions. It has a 3' long conserved untranslated region (3'LCU)-mediated fine-tuning system for mRNA regulation in early vertebrate development such as anteroposterior (AP) patterning and signal transduction. MEX3B contains two K homology (KH) domains that provide RNA-binding capacity, and a C-terminal C3HC4-type RING-HC finger. Like other MEX-3 family proteins, MEX3B shuttles between the nucleus and the cytoplasm via the CRM1-dependent export pathway.
Statistics
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PSSM-Id: 319635
View PSSM: cd16721
Aligned: 7 rows
Threshold Bit Score: 101.116
Threshold Setting Gi: 675372563
Created: 20-Mar-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Mus musculus Hakai (3VK6) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
Feature 1          #  #           # #   #  #           #  # 
gi 74762391  516 RDCSVCFESEVIAALVPCGHNLFCMECANRICEKsePECPVCH 558
gi 465960980 323 RDCSICFESEVIAALVPCGHNLFCMECANRICEKtePQCPVCH 365
gi 134034169 454 RECSICFESEVIAALVPCGHNLFCMECANRICEKnqPQCPVCH 496
gi 556956983 481 RDCSICFESEVIAALVPCGHNLFCMECANRICEKsePQCPVCH 523
gi 124430528 484 RDCSVCFESEVIAALVPCGHNLFCMECANRICERnePKCPVCH 526
gi 585645368 475 KECMMCFESEVVAALVPCGHNLFCMECANRLMEKsdPECPVCH 517
gi 675372563 469 RDCAVCFESEIVAALVPCGHNMFCLECANRICEKaePECPICR 511

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