Conserved Protein Domain Family
RING-HC_MEX3C

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cd16722: RING-HC_MEX3C 
RING finger, HC subclass, found in RNA-binding protein MEX3C
MEX3C, also known as RING finger and KH domain-containing protein 2 (RKHD2), or RING finger protein 194 (RNF194), is a RNA-binding phosphoprotein that acts as a suppressor of chromosomal instability. It functions as a RNA-binding ubiquitin E3 ligase responsible for the post-transcriptional, HLA-A allotype-specific regulation of MHC class I molecules (MHC-I). It also modifies retinoic acid inducible gene-1 (RIG-I) in stress granules and plays a critical role in eliciting antiviral immune responses. Moreover, MEX3C plays an essential role in normal postnatal growth via enhancing the local expression of insulin-like growth factor 1 (IGF1) in bone. It may also be involved in metabolic regulation of energy balance. MEX3C contains two K homology (KH) domains that provide RNA-binding capacity, and a C-terminal C3HC4-type RING-HC finger. Like other MEX-3 family proteins, MEX3C shuttles between the nucleus and the cytoplasm via the CRM1-dependent export pathway.
Statistics
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PSSM-Id: 319636
View PSSM: cd16722
Aligned: 3 rows
Threshold Bit Score: 89.2806
Threshold Setting Gi: 676830374
Created: 20-Mar-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Mus musculus Hakai (3VK6) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
Feature 1          #  #           # #   #  #           #  # 
gi 134047827 606 HDCVICFENEVIAALVPCGHNLFCMECANKICEKrtPSCPVCQ 648
gi 676830374 355 HDCVICFESEVIAALVPCGHNLFCMECANKICEKetPSCPVCQ 397
gi 147904537 440 HDCVICFDNEVIAALVPCGHNLFCMDCANKICEKdlPLCPVCQ 482

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