Conserved Protein Domain Family
RING1-HC_MIB1

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cd16724: RING1-HC_MIB1 
RING finger 1, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
MIB1, also known as DAPK-interacting protein 1 (DIP-1) or zinc finger ZZ type with ankyrin repeat domain protein 2, is a large, multi-domain E3 ubiquitin-protein ligase that promotes ubiquitination of the cytoplasmic tails of Notch ligands, and thus plays an essential role in controlling metazoan development by Notch signaling. It is also involved in Wnt/beta-catenin signaling and nuclear factor (NF)-kappaB signaling, and has been implicated in innate immunity, neuronal function, genomic stability, and cell death. MIB1 contains an MZM region with two Mib-Herc2 domains flanking a ZZ zinc finger, a REP region including two tandem Mib repeats, an ANK region that spans ankyrin repeats, and a RNG region consisted of three C3HC4-type RING-HC fingers. This family corresponds to the first RING-HC finger.
Statistics
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PSSM-Id: 319638
View PSSM: cd16724
Aligned: 17 rows
Threshold Bit Score: 55.9045
Threshold Setting Gi: 156223774
Created: 2-May-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens RNF123 (2MA6) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30
                  ....*....|....*....|....*....|....*..
Feature 1          #  #           # #   #  #      #  # 
gi 68565512   818 ECMVCSDMKRDTLFGPCGHIATCSLCSPRVKKCLICK 854
gi 68565488   819 ECMVCSDLKRDTLFGPCGHIATCSLCSPRVKKCLLCK 855
gi 405964136  196 ECMVCSDLKRDTLFGPCGHIATCSLCSPRVKKCLMCK 232
gi 443712746   86 ECMVCSDMKRDTLFGPCGHIATCSLCSPRVKKCLMCK 122
gi 321479040  211 ECMVCSDLKRDTLFGPCGHVNCCSACAPRVKKCLVCK 247
gi 68565370   969 ECLVCSDAKRDTVFKPCGHVSCCETCAPRVKKCLICR 1005
gi 156223774   13 ECMVCSDNKRDTLFGPCGHVATCSLCSPRVKKCLMCK 49
gi 699238143  921 ECMICSDSPRDTILEPCGHSLACASCSDRIKKCLLCK 957
gi 215501673   79 DCIVCSDMKRDTLFGPCGHIATCSLCSPRVKKCLMCK 115
gi 919003623  821 ECMVCSDMKRDTLFGPCCHIATCSLCSPRVKKCLMCK 857

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