Conserved Protein Domain Family
RING2-HC_MIB2

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cd16728: RING2-HC_MIB2 
RING finger 2, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
MIB2, also known as novel zinc finger protein (Novelzin), putative NF-kappa-B-activating protein 002N, skeletrophin, or zinc finger ZZ type with ankyrin repeat domain protein 1, is a large, multi-domain E3 ubiquitin-protein ligase that promotes ubiquitination of the cytoplasmic tails of Notch ligands. Especially, it promotes Delta ubiquitylation and endocytosis in Notch activation. Overexpression of MIB2, activates NF-kappaB and interferon-stimulated response element (ISRE) reporter activity. Moreover, MIB2 acts as a novel component of the activated B-cell CLL/lymphoma 10 (BCL10) complex and controls BCL10-dependent NF-kappaB activation. It also functions as a founder myoblast-specific protein that regulates myoblast fusion and muscle stability. MIB2 contains an MZM region with two Mib-Herc2 domains flanking a ZZ zinc finger, a REP region including two tandem Mib repeats, an ANK region that spans ankyrin repeats, and a RNG region consisted of two C3HC4-type RING-HC fingers. This family corresponds to the second RING-HC finger.
Statistics
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PSSM-Id: 319642
View PSSM: cd16728
Aligned: 6 rows
Threshold Bit Score: 103.377
Threshold Setting Gi: 209572707
Created: 21-Mar-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens Parkin (5C1Z) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
Feature 1          #  #          # #  #  #      #  #            
gi 209572707  968 TCPICIDsHIRLVFQCGHGACAPCGSALSACPICRQPIRDRIQIFV 1013
gi 190337136  953 TCPICIDnHIRLVFQCGHASCIDCSSALKTCPICRQTIRERIQLFV 998
gi 189217792  906 TCPICIDsHIKLVFQCGHGSCTECSSSLTACPICRQVIREKIQIFV 951
gi 68565462   909 TCPICIDdQIKLVFQCGHGSCPDCSTALTVCPICRQAIRERIQIFV 954
gi 556945373  897 MCPICLDnHIKLVFQCGHGSCIECSVALKVCPICRQAIRERIQIFV 942
gi 632977625  797 TCPICIDnQIKLVFQCGHGSCLECSVALKACPICRQNIRERIQIFV 842

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