Conserved Protein Domain Family
RING-HC_MKRN2

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cd16731: RING-HC_MKRN2 
RING finger, HC subclass, found in makorin-2 (MKRN2) and similar proteins
MKRN2, also known as makorin RING finger protein 2, RING finger protein 62 (RNF62), or HSPC070, is a putative ribonucleoprotein that acts as a neurogenesis inhibitor acting upstream of glycogen synthase kinase-3beta (GSK-3beta) in the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. It also functions on promoting cell proliferation of primary CD34+ progenitor cells and K562 cells, indicating its possible involvement in normal and malignant hematopoiesis. Mammalian MKRN2 contains three N-terminal C3H1-type zinc fingers, a motif rich in Cys and His residues (CH), a C3HC4-type RING-HC finger, and another C3H1-type zinc finger at the C-terminus. The third C3H1-type zinc finger, the CH motif, as well as the RING zinc finger are necessary for its anti-neurogenic activity.
Statistics
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PSSM-Id: 319645
View PSSM: cd16731
Aligned: 6 rows
Threshold Bit Score: 114.227
Threshold Setting Gi: 221222463
Created: 25-Mar-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens RNF144A (1WIM) binds two Zn2+ ions through its C4C4-type RING finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
Feature 1           #  #                    # #  #  #                 #  # 
gi 45645205  235 DKVCSICMEVILEKasaSERRFGILSNCNHTYCLSCIRQWRCAKQFENpIIKSCPECR 292
gi 632970210 248 DKVCNICMEVVYEKpilSERRFGILSDCIHPYCLSCIRQWRCAKQFENkIIKSCPECR 305
gi 557005586 193 DKVCSICMEVVYDKataSERRFGILSNCSHTYCLSCIRQWRCAKQFENkIIKSCPECR 250
gi 45383560  234 DKVCSICMEVVYEKpsaSERRFGILSNCNHTYCLSCIRQWRCAKQFENpIIKSCPECR 291
gi 221272069 227 GRVCSICMERVYEKqspAQRRFRILSDCNHTYCLTCIRQWRCARQFDNpVIKSCPECR 284
gi 221222463 234 DKVCKICLDVVYEKsspSERRFGILSSCAHTYCLNCIRQWRCVEQLHNqIRKSCPECR 291

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