Conserved Protein Domain Family
RING-HC_MKRN4
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cd16732: RING-HC_MKRN4 
RING finger, HC subclass, found in makorin-4 (MKRN4) and similar proteins
MKRN4, also known as makorin RING finger protein pseudogene 4, makorin RING finger protein pseudogene 5, RING finger protein 64 (RNF64), zinc finger protein 127-Xp (ZNF127-Xp), or zinc finger protein 127-like 1, is a new divergent member of the makorin protein family in vertebrates. It may have an ancestral gonad-specific function and maternal embryonic expression before duplication in vertebrates. MKRN4 contains typical arrays of one to four C3H1-type zinc fingers, a motif rich in Cys and His residues (CH) and a C3HC4-type RING-HC finger. The RING-HC finger of mammalian MKRN4 shows high sequence similarity with that of MKRN3, and is not included in this model.
Links
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Statistics
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PSSM-Id: 438390
Aligned: 6 rows
Threshold Bit Score: 117.598
Created: 14-Sep-2015
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #  #                    # #  #  #                 #  #    
NP_001135584 181 DVVCGICMDKVYEKqv-aERVFGILPNCSHAYCVGCIKRWRKTRDFqneVIKGCPQCRIKS 240 western clawed frog
EMP32330     607 DVVCGICMDKVYEKalpeERVFGILPNCSHAYCVGCIRKWRKSREFqnaVIKACPECRVTS 667 green sea turtle
NP_001121808 231 DVACGICMDKISEKstaqERRYGILPNCNHAFCIGCIVTWRKTKDFqeeVIKGCPQCRVKS 291 zebrafish
XP_007892311 277 EMACGICMDTVYEKtharERVFAILPHCNHTFCVTCIKKWRNSRGFtnkIIKACPECRVVS 337 elephant shark
XP_005988540 203 NVTCGICMDRVYEKshpgERKFGILPNCNHAYCVSCIKKWRKSKDFqseIIKSCPECRVKS 263 coelacanth
NP_001123332 238 EIACGICMEVVWEKadekDRKFGILENCNHTFCLDCIRKWRSAKAFnntVVRACPQCRVSS 298 Ciona intestinalis

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