Conserved Protein Domain Family
RING-HC_MKRN4

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cd16732: RING-HC_MKRN4 
RING finger, HC subclass, found in makorin-4 (MKRN4) and similar proteins
MKRN4, also known as makorin RING finger protein pseudogene 4, makorin RING finger protein pseudogene 5, RING finger protein 64 (RNF64), zinc finger protein 127-Xp (ZNF127-Xp), or zinc finger protein 127-like 1, is a new divergent member of the makorin protein family in vertebrates. It may have an ancestral gonad-specific function and maternal embryonic expression before duplication in vertebrates. MKRN4 contains typical arrays of one to four C3H1-type zinc fingers, a motif rich in Cys and His residues (CH) and a C3HC4-type RING-HC finger. The RING-HC finger of mammalian MKRN4 shows high sequence similarity with that of MKRN3, and is not included in this subfamily.
Statistics
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PSSM-Id: 319646
View PSSM: cd16732
Aligned: 4 rows
Threshold Bit Score: 120.764
Threshold Setting Gi: 632953244
Created: 14-Sep-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens RNF144A (1WIM) binds two Zn2+ ions through its C4C4-type RING finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
Feature 1           #  #                    # #  #  #                 #  #    
gi 213982833 181 DVVCGICMDKVYEKqv-aERVFGILPNCSHAYCVGCIKRWRKTRDFqneVIKGCPQCRIKS 240
gi 465970328 607 DVVCGICMDKVYEKalpeERVFGILPNCSHAYCVGCIRKWRKSREFqnaVIKACPECRVTS 667
gi 190358560 231 DVACGICMDKISEKstaqERRYGILPNCNHAFCIGCIVTWRKTKDFqeeVIKGCPQCRVKS 291
gi 632953244 277 EMACGICMDTVYEKtharERVFAILPHCNHTFCVTCIKKWRNSRGFtnkIIKACPECRVVS 337

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