Conserved Protein Domain Family
RING-HC_PCGF3

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cd16735: RING-HC_PCGF3 
RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
PCGF3, also known as RING finger protein 3A (RNF3A), is one of six PcG RING finger (PCGF) homologs (PCGF1, PCGF2/Mel-18, PCGF3, PCGF4/BMI1, PCGF5, and PCGF6) and serves as the core component of a Polycomb repressive complex 1 (PRC1). Like other PCGF homologs, PCGF3 associates with ring finger protein 2 (RNF2) to form a RNF2-PCGF heterodimer, which is catalytically competent as an E3 ubiquitin transferase and is the scaffold for the assembly of additional components. PCGF3 contains a C3HC4-type RING-HC finger.
Statistics
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PSSM-Id: 319649
View PSSM: cd16735
Aligned: 17 rows
Threshold Bit Score: 74.8176
Threshold Setting Gi: 156216182
Created: 18-Mar-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens PCGF4 (3PRG) binds two Zn2+ ions thorugh its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
Feature 1           #  #            # #  #  #           #  #     
gi 121942537  14 HITCRLCSGYLIDATTVTECLHTFCRSCLVKYLEe-NNTCPTCRIVIH 60
gi 260827951  14 HITCMLCKGYLVDATTITECLHTFCKSCIVQYLEe-NNDCPTCKQVIH 60
gi 215498024  13 HIICKICKGYLIDATTVTECLHTFCKSCLVKHLEd-NNTCPTCEIVIH 59
gi 392901078 326 FITCGICDGYIVDATTIIDCMHTFCKSCLLTYFEsdNNTCPTCGTFIH 373
gi 585655846  13 HITCRICHGYFIDATTITECLHTFCKSCIVRYLEe-HNTCPTCGIVIH 59
gi 918316507  14 HITCTLCSGYLIDATTITECLHTFCKSCLVQYLDd-NNTCPTCEIVIH 60
gi 321455673  13 HIICKICGGYLIDATTVTECLHTFCKSCLVKHLEe-NNTCPSCNIMIH 59
gi 675868828  21 CITCMLCKGYMIEATTITECLHTFCKSCIVKFLEe-NNTCPKCGLVIH 67
gi 17864614   13 HITCKICGGYFIDATTVTECLHTFCKSCLVKHLEe-KKTCPTCDNIIH 59
gi 198426367  30 HITCYLCHGYLIDATTITECLHTFCKSCIVSHVEdgRNECPKCEAVIH 77

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