4S3O


Conserved Protein Domain Family
RING-HC_PCGF5

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cd16737: RING-HC_PCGF5 
Click on image for an interactive view with Cn3D
RING finger found in polycomb group RING finger protein 5 (PCGF5) and similar proteins
PCGF5, also known as RING finger protein 159 (RNF159), is one of six PcG RING finger (PCGF) homologs (PCGF1/NSPc1, PCGF2/Mel-18, PCGF3, PCGF4/BMI1, PCGF5, and PCGF6/MBLR) and serves as the core component of a Polycomb repressive complex 1 (PRC1). Like other PCGF homologs, PCGF5 associates with ring finger protein 2 (RNF2) to form a RNF2-PCGF heterodimer, which is catalytically competent as an E3 ubiquitin transferase and is the scaffold for the assembly of additional components. PCGF5 contains a C3HC4-type RING-HC finger.
Statistics
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PSSM-Id: 319651
View PSSM: cd16737
Aligned: 12 rows
Threshold Bit Score: 76.6937
Threshold Setting Gi: 470289799
Created: 3-May-2013
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Structure:4S3O; Homo sapiens PCGF5 binds two Zn2+ ions through its RING-HC finger, contacts at 4A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
Feature 1           #  #            # #  #  #                       #  # 
4S3O_C         16 ITCYICKGYLIKPTTVTECLHTFCKTCIVQHFEds-------------nDCPRCG 57
gi 123887311   16 ITCFVCKGYLIKPTTVTECLHTFCKSCIVQHFEds-------------nDCPKCG 57
gi 475504246   16 ITCYICKGYLIKPTTVTECLHTFCKTCIVQHFEds-------------nDCPRCG 57
gi 306755928   16 ITCSICRGYLIKPTAVTECLHTFCKSCIVQHFEes-------------nECPECG 57
gi 313239220   22 ISCSFCKGYLVEPTVIPECSHTFCRTCILRHFQde-------------lDCPECG 63
gi 557011578   16 ITCFICKGYLIKPTTVTECLHTFCKSCIVQHFEds-------------nDCPRCG 57
gi 632936438   16 ITCYVCKGYLIKPTTVTECLHTFCKSCIVQHFEdt-------------nDCPKCG 57
gi 585695713   14 ITCSICGGYLIKPSTIAECLHTFCKSCIVRHFEes-------------kNCPRCG 55
gi 74750353    16 ITCYICKGYLIKPTTVTECLHTFCKTCIVQHFEds-------------nDCPRCG 57
gi 512852154   16 ITCYICKGYLIKPTTVTECLHTFCKTCIVQHFEes-------------nDCPKCG 57
gi 76803821    33 ITCRLCRGYMIDPTTVDYCYHTYCRSCILKHLLra-------------vYCPECK 74
gi 470289799   76 LVCRICLGYCVTPTVIVECMHPFCKSCIVKHIRttrwnatrkklpniqvLCPECD 130

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