Conserved Protein Domain Family
RING-HC_RING1

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cd16739: RING-HC_RING1 
RING finger, HC subclass, found in really interesting new gene 1 protein (RING1) and similar proteins
RING1, also known as polycomb complex protein RING1, RING finger protein 1 (RNF1), or RING finger protein 1A (RING1A), was identified as a transcriptional repressor that is associated with the Polycomb group (PcG) protein complex involved in stable repression of gene activity. It is a core component of polycomb repressive complex 1 (PRC1) that functions as an E3-ubuiquitin ligase that transferring the mono-ubuiquitin mark to the C-terminal tail of Histone H2A at K118/K119. PRC1 is also capable of chromatin compaction, a function not requiring histone tails, and this activity appears important in gene silencing. RING1 interacts with multiple PcG proteins and displays tumorigenic activity. It also shows zinc-dependent DNA binding activity. Moreover, RING1 inhibits transactivation of the DNA-binding protein recombination signal binding protein-Jkappa (RBP-J) by Notch through interaction with the LIM domains of KyoT2. RING1 contains a C3HC4-type RING-HC finger.
Statistics
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PSSM-Id: 319653
View PSSM: cd16739
Aligned: 8 rows
Threshold Bit Score: 88.6424
Threshold Setting Gi: 50401702
Created: 22-Mar-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens RING1B (4R8P) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
Feature 1         #  #            # #  #  #           #  #   
gi 90110053   47 MCPICLDMLKnTMTTKECLHRFCSDCIVTALRsGNKECPTCRKK 90
gi 90101656   46 MCPICLDMLKnTMTTKECLHRFCSDCIVTALRsGNKECPTCRKK 89
gi 62900962   47 MCPICLDMLKnTMTTKECLHRFCSDCIVTALRsGNKECPTCRKK 90
gi 321459285  46 MCPICLDMLKnTMTTKECLHRFCSDCIITALRsGNKECPTCRKK 89
gi 50401702   45 MCPICLDMLKkTMTTKECLHRFCSDCIVTALRsGNKECPTCRKK 88
gi 307147576  47 MCPICLDMLKnTMTTKECLHRFCSDCIVTALRsGNKECPTCRKK 90
gi 697418986  24 MCPICLDMLKnTMTTKECLHRFCSDCIVTALRsGNKECPTCRKK 67
gi 556993781  47 MCPICLDMLKnTMTTKECLHRFCSDCIVTALRsGNKECPTCRKK 90

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