4R8P,2CKL,3RPG,2H0D,4S3O


Conserved Protein Domain Family
RING-HC_RING2

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cd16740: RING-HC_RING2 
Click on image for an interactive view with Cn3D
RING finger, HC subclass, found in really interesting new gene 2 protein (RING2) and similar proteins
RING2, also known as huntingtin-interacting protein 2-interacting protein 3, HIP2-interacting protein 3, protein DinG, RING finger protein 1B (RING1B), RING finger protein 2 (RNF2), or RING finger protein BAP-1, is an E3 ubiquitin-protein ligase that interacts with both nucleosomal DNA and an acidic patch on histone H4 to achieve the specific monoubiquitination of K119 on histone H2A (H2AK119ub), thereby playing a central role in histone code and gene regulation. RING2 is a core component of polycomb repressive complex 1 (PRC1) that functions as an E3-ubuiquitin ligase transferring the mono-ubuiquitin mark to the C-terminal tail of Histone H2A at K118/K119. PRC1 is also capable of chromatin compaction, a function not requiring histone tails, and this activity appears important in gene silencing. The enzymatic activity of RING2 is enhanced by the interaction with BMI1/PCGF4, and it is dispensable for early embryonic development and much of the gene repression activity of PRC1. Moreover, RING2 plays a key role in terminating neural precursor cell (NPC)-mediated production of subcerebral projection neurons (SCPNs) during neocortical development. It also plays a critical role in nonhomologous end-joining (NHEJ)-mediated end-to-end chromosome fusions. Furthermore, RING2 is essential for expansion of hepatic stem/progenitor cells. It promotes hepatic stem/progenitor cell expansion through simultaneous suppression of cyclin-dependent kinase inhibitors (CDKIs) Cdkn1a and Cdkn2a, known negative regulators of cell proliferation. RING2 also negatively regulates p53 expression through directly binding with both p53 and MDM2 and promoting MDM2-mediated p53 ubiquitination in selective cancer cell types to stimulate tumor development. RING2 contains a C3HC4-type RING-HC finger.
Statistics
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PSSM-Id: 319654
View PSSM: cd16740
Aligned: 10 rows
Threshold Bit Score: 81.646
Threshold Setting Gi: 109158141
Created: 22-Mar-2015
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
Feature 1            #  #            # #  #  #           #  #   
4R8P_L        47 SELMCPICLDMLKNTMTTKECLHRFCADCIITALRsGNKECPTCRKK 93
2CKL_B        53 SELMCPICLDMLKNTMTTKECLHRFCADCIITALRsGNKECPTCRKK 99
3RPG_C        52 SELMCPICLDMLKNTMTTKECLHRFCADCIITALRsGNKECPTCRKK 98
2H0D_B        33 SELMCPICLDMLKNTMTTKECLHRFCADCIITALRsGNKECPTCRKK 79
gi 62901019   47 SELMCPICLDMLKNTMTTKECLHRFCADCIITALRsGNKECPTCRKK 93
gi 677539024  47 SELMCPICLDMLKNTMTTKECLHRFCADCIITALRsGNKECPTCRKK 93
gi 632956080  49 SELMCPICLDMLKNTMTTKECLHRFCADCIVTALRsGNKECPTCRKK 95
gi 62901044   47 SELMCPICLDMLKNTMTTKECLHRFCADCIITALRsGNKECPTCRKK 93
4S3O_B        49 SELMCPICLDMLKNTMTTKECLHRFCADCIITALRsGNKECPTCRKK 95
gi 163914471  47 SELMCPICLDMLKNTMTTKECLHRFCADCIITALRsGNKECPTCRKK 93

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