Conserved Protein Domain Family
RING-HC_RNFT1
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cd16741: RING-HC_RNFT1 
RING finger, HC subclass, found in RING finger and transmembrane domain-containing protein 1 (RNFT1)
RNFT1, also known as protein PTD016, is a multi-pass membrane protein containing a C3HC4-type RING-HC finger. Its biological role remains unclear.
Links
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Statistics
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PSSM-Id: 438399
Aligned: 6 rows
Threshold Bit Score: 123.842
Created: 24-Mar-2015
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                        #  #           # #  #  #          #  #    
Q5M7Z0       359 YGVAASKRQCSDVDDICSICQAEFqkPILLICQHIFCEECMTLWFNREKTCPLCRTVI 416 human
XP_007904358 400 YGIAASQHQCSDAGEICPICQAEFrePVLLTCQHIFCEECISLWFNREKTCPLCRTVI 457 elephant shark
XP_005986872 312 YGITASKRQCLEAGDICPICQAEFrdPILLVCQHVFCEECISLWFNREKTCPLCRTVI 369 coelacanth
Q28GL3       340 YGAAATKSQCSEVDGMCAICQAEFikPIVLVCQHVFCEECISLWFNKEKTCPLCRTVI 397 tropical clawed frog
Q6NTV1       340 YGTTATKRQCSEADGMCAICQAEFtkPIALICQHVFCEECISSWFNKEKTCPLCRTLI 397 African clawed frog
XP_415883    307 YGVTASKRQCSESDDICSICHAEFqkPILLICQHTFCEECISLWFNREKTCPLCRTVI 364 chicken

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