Conserved Protein Domain Family
RING-HC_RNF212

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cd16746: RING-HC_RNF212 
RING finger, HC subclass, found in RING finger protein 212 (RNF212) and similar proteins
RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis. It plays a central role in designating crossover sites and coupling chromosome synapsis to the formation of crossover-specific recombination complexes. It also functions as an E3 ligase for SUMO modification. RNF212 contains an N-terminal C3HC4-type RING-HC finger.
Statistics
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PSSM-Id: 319660
View PSSM: cd16746
Aligned: 4 rows
Threshold Bit Score: 86.7603
Threshold Setting Gi: 121943260
Created: 24-Mar-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens TFIIH MAT1 subunit (1G25) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
Feature 1           #  #               # #  #  #        #  #     
gi 121943260   4 WVFCNRCFQPPHrt-scFSLTNCGHVYCDACLGKGKKnECLICKAPCR 50
gi 556974124   4 WVYCNTCFQQPRtdnnsLYLTNCGHVFCQSCLQKGRKnECLVCGVHCR 51
gi 632960404   4 RIFCNFCFQQPRpnccsFALTNCGHVVCEACLKKGSMkKCCVCKADCR 51
gi 591378454   4 LVFCNVCFRQPRtatprFCLTNCGHVICEPCLQKGKKdECLICRAPCR 51

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