Conserved Protein Domain Family
RING-HC_TRIM46

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cd16757: RING-HC_TRIM46 
RING finger, HC subclass, found in tripartite motif-containing protein 46 (TRIM46) and similar proteins
TRIM46, also known as gene Y protein (GeneY) or tripartite, fibronectin type-III and C-terminal SPRY motif protein (TRIFIC), is a microtubule-associated protein that specifically localizes to the proximal axon, partly overlaps with the axon initial segment (AIS) at later stages, and organizes uniform microtubule orientation in axons. It controls neuronal polarity and axon specification by driving the formation of parallel microtubule arrays. TRIM46 belongs to the C-I subclass of TRIM (tripartite motif) family of proteins, which are defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, Bbox1 and Bbox2, and a coiled coil region, as well as a COS (carboxyl-terminal subgroup one signature) box, a fibronectin type III (FN3) domain, and a B30.2/SPRY (SplA and ryanodine receptor) domain positioned C-terminal to the RBCC domain.
Statistics
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PSSM-Id: 319671
View PSSM: cd16757
Aligned: 4 rows
Threshold Bit Score: 70.238
Threshold Setting Gi: 131886491
Created: 3-May-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Mus musculus Hakai (3VK6) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #  #           # #  #  #                                                  
gi 55976496   27 MEKELLCPVCQEMYKQPLVLPCTHNVCQACAREVLgqqgyighggdpsseptspastpstrsprlsrrtlpkpdrldrll 106
gi 131886491   4 MEQELQCPVCKDIVKQPIVLPCLHSVCLMCASEVLiqsgypqpelppepnspastpnmrsprqmrrp--mpksdrvdrll 81
gi 465959034  27 MERELICPVCKEMYKQPLALPCMHNVCHVCASEILvqhgyiccdpsseptspastpatrsprmgrrrdvdlgerglgnlf 106
gi 557013617  27 IERELLCPICKEMYKQPIILPCMHNVCLLCATEVLiqhgyvctdpnsepsspastpatrsprmgrrv--tpkpdrldrvi 104
                         90       100
                 ....*....|....*....|....*....
Feature 1                               #  #  
gi 55976496  107 ksgfgtypgrkrgalhpqvimFPCPACQG 135
gi 131886491  82 rsgsgtypgrrrkdgppplmlFPCAPCGR 110
gi 465959034 107 rnltlervveryrqtinistaIVCQFCKP 135
gi 557013617 105 rsgfgtypgrrrgashaqsilFPCPSCHR 133

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