Conserved Protein Domain Family
RING-HC_UNKL

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cd16772: RING-HC_UNKL 
RING finger, HC subclass, found in RING finger protein unkempt-like (UNKL) and similar proteins
UNKL, also known as zinc finger CCCH domain-containing protein 5-like, is a putative E3 ubiquitin-protein ligase that may participate in a protein complex showing an E3 ligase activity regulated by RAC1. It shows high sequence similarity with RING finger protein unkempt (UNK), which is a metazoan-specific zinc finger protein enriched in embryonic brains, and may play a broad regulatory role during the formation of the central nervous system (CNS). UNKL contains several CCCH-type zinc fingers at the N-terminus, and a C3HC4-type RING-HC finger at its C-terminus.
Statistics
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PSSM-Id: 319686
View PSSM: cd16772
Aligned: 4 rows
Threshold Bit Score: 73.7465
Threshold Setting Gi: 300669704
Created: 17-Sep-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Mus musculus Hakai (3VK6) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30
                 ....*....|....*....|....*....|....*...
Feature 1          #  #           # #   #  #      #  # 
gi 300669704 637 KQCVACRERAHGAVLRPCQHHILCEPCAAtapECPYCK 674
gi 632985065 190 KKCIVCQERDRSILLQPCQHYVLCEHCAPnniECPYCK 227
gi 183986651 714 KKCIVCHEQERSIVLQPCQHYVLCEQCATskpECPYCK 751
gi 528474948 712 KKCIVCQKHDRSIVLQPCQHYVLCQNCASgkkECPYCK 749

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