Conserved Protein Domain Family
RING-HC_RBR_ANKIB1

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cd16774: RING-HC_RBR_ANKIB1 
RING finger, HC subclass, found in ankyrin repeat and IBR domain-containing protein 1 (ANKIB1) and similar proteins
ANKIB1 is a RBR-type E3 ubiquitin-protein ligase that may function as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. It contains an N-terminal ankyrin repeats domain and a RBR domain that was previously known as RING-BetweenRING-RING domain or TRIAD [two RING fingers and a DRIL (double RING finger linked)] domain. Based on current understanding of the structural biology of RBR ligases, the nomenclature of RBR has been corrected as RING-BRcat (benign-catalytic)-Rcat (required-for-catalysis) recently. The RBR (RING1-BRcat-Rcat) domain use an auto-inhibitory mechanism to modulate ubiquitination activity, as well as a hybrid mechanism that combines aspects from both RING and HECT E3 ligase function to facilitate the ubiquitination reaction. This family corresponds to the RING domain, a C3HC4-type RING-HC finger required for RBR-mediated ubiquitination.
Statistics
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PSSM-Id: 319688
View PSSM: cd16774
Aligned: 12 rows
Threshold Bit Score: 117.539
Threshold Setting Gi: 229290467
Created: 27-Jan-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
Conserved Features/SitesClick to see Conserved Features Help
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens HHARI (4KBL) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
Feature 1          #  #              # #  #  #                  #    #     
gi 158937428  332 LCDICMCSIsvfEDPVDMPCGHDFCRGCWESFLNLKIQEGeaHNIFCPAYDCFQLVP 388
gi 170284564  333 LCGICMCNIsvfEDPVEIPCGHEFCRVCWESFLNLKIQEGeaHNIFCPAYDCFQLVP 389
gi 449280432  334 VCDICMCNIsvfEDPVDMPCGHDFCRACWEAFLNLKIQEGeaHNIFCPAYDCFQLVP 390
gi 123906973  333 LCGICMSSIsvfEDPVDMSCGHEFCRACWEGFLNLKIQEGeaHNIFCPAYDCFQLVP 389
gi 632959640  333 VCGICMCSIsvfEDPVDVPCGHEFCRACWEGFLNIKIQEGeaHNIFCPAFDCYQLVP 389
gi 291229428  303 VCDICAGSIaftEEPVDMPCNHQFCRECWQSYLTGKIQEGnaHNIRCPAFDCTKLVP 359
gi 443723196  309 VCDICACTIpspEEPVNMTCDHQFCRSCWERYLTGKIIEGeaHNIYCPGYECCRLVP 365
gi 229290467  322 LCDICAGPVsadDEPVDIPCAHQFCQECWERYLSLKIKDGstGDIQCPGYECSQLVP 378
gi 675850562  274 ECGICACPIsqmEPPVLMPCNHQFCRTCWEVYLSNKISDGetHNMTCAGYQCNKLVP 330
gi 115918148  320 ECDICTELIsreESPVEMPCPHHFCKMCWERYLSGKIAEGnaHNIMCPAFECCKLVP 376
gi 919002917  315 LCDICANYIpsdETAVPMSCEHRFCRACWEGYLNVKIQEGeaHNITCPAYDCIKLVP 371
gi 918337521  188 ICDICTCTFmmsEEPVHMPCEHRFCRSCWEQYLNLKIQEGdaHHITCPGYDCSRLVP 244

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