4TXA


Conserved Protein Domain Family
mRING-HC-C3HC3D_Roquin1

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cd16781: mRING-HC-C3HC3D_Roquin1 
Click on image for an interactive view with Cn3D
Modified RING finger, HC subclass (C3HC3D-type), found in Roquin-1
Roquin-1, also known as RING finger and C3H zinc finger protein 1 (RC3H1), or RING finger protein 198 (RNF198), is a ubiquitously expressed RNA-binding protein essential for degradation of inflammation-related mRNAs and maintenance of immune homeostasis. It is localized in cytoplasmic granules and binds to the 3' untranslated region (3'UTR) of inducible costimulator (ICOS) mRNA to post-transcriptionally repress its expression. Roquin-1 interacts with 3'UTR of tumor necrosis factor receptor superfamily member 4 (TNFRSF4) and tumor-necrosis factor-alpha (TNFalpha), and post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-kappaB pathway. Moreover, Roquin-1 shares functions with its paralog Roquin-2 in the repression of mRNAs controlling T follicular helper cells and systemic inflammation. Roquin-1 contains an N-terminal modified C3HC3D-type RING-HC finger with a potential E3 ubiquitin-ligase function, a highly conserved ROQ domain required for RNA binding and localization to stress granules, and a CCCH-type zinc finger that is involved in RNA recognition, typically contacting AU-rich elements. In addition, both N- and C-terminal to the ROQ domain are combined to form a HEPN (higher eukaryotes and prokaryotes nucleotide-binding) domain that is highly likely to function as a RNA-binding domain.
Statistics
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PSSM-Id: 319695
View PSSM: cd16781
Aligned: 6 rows
Threshold Bit Score: 100.037
Threshold Setting Gi: 767259555
Created: 19-Mar-2015
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding sitemodified
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Structure:4TXA; Mus musculus Roquin binds two Zn2+ ions, contacts at 4A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
Feature 1            #  #               # #  #           #  # 
4TXA_A         11 FLSCPICTQTFDETiRKPISLGCGHTVCKMCLNKLHRKACPFDQ 54
gi 73621450    11 FLSCPICTQTFDETiRKPISLGCGHTVCKMCLNKLHRKACPFDQ 54
gi 167963526   11 FLLCPICTQTFEETvRRPISLGCGHTVCKMCLNKLHRKACPFDQ 54
gi 73621452    11 FLSCPICTQTFDETiRKPISLGCGHTVCKMCLNKLHRKACPFDQ 54
gi 449275847   11 FLSCPICTQTFDETiRKPISLGCGHTVCKMCLNKLHRKACPFDQ 54
gi 632969509   11 FLSCPICCRTFDENvRKPISLGCGHTLCSICLNNLHRKACPFDH 54

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