Conserved Protein Domain Family
mRING-HC-C3HC5_NEU1B

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cd16786: mRING-HC-C3HC5_NEU1B 
Modified RING finger, HC subclass (C3HC5-type), found in neuralized-like protein 1B (NEURL1B)
NEURL1B, also known as neuralized-2 (NEUR2) or neuralized-like protein 3, is a mammalian homolog of the Drosophila neuralized (D-neu) protein. It functions as an E3 ubiquitin-protein ligase that interacts with and ubiquitinates Delta. Thus, it plays a role in the endocytic pathways for Notch signaling through working cooperatively with another E3 ligase, Mind bomb-1 (Mib1), in Delta endocytosis to hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs)-positive vesicles. NEURL1B contains two neuralized homology regions (NHRs) responsible for Neural-ligand interactions and a modified C3HC5-type RING-HC finger required for ubiquitin ligase activity. The C3HC5-type RING-HC finger is distinguished from typical C3HC4-type RING-HC finger due to the existence of the additional cysteine residue in the middle portion of the RING finger domain.
Statistics
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PSSM-Id: 319700
View PSSM: cd16786
Aligned: 6 rows
Threshold Bit Score: 98.0684
Threshold Setting Gi: 301624609
Created: 29-Jul-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding sitemodified
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens Parkin (5C1Z) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
Feature 1         #  #           # #   #  #           #  #  
gi 205829224 502 ECTVCFDgEVDTVIYTCGHMCLCHSCGLRLKRQaRACCPICRR 544
gi 301624609 500 ECAVCFDnEVETVIYTCGHMCLCSSCGLKLKRQvNACCPICRR 542
gi 118097322 503 ECTVCFDnEVDTVIYTCGHMCLCNTCGLKLKKQlNACCPICRR 545
gi 556966322 499 ECTVCFDsEVDTVIYTCGHMCLCNSCGLKLKKQsNACCPICRR 541
gi 632966727 492 ECTVCFDsEVETVIYTCGHMCLCYDCGLKLKKQiNACCPICRR 534
gi 528499613 507 ECTVCFDqEVDTVIYTCGHMCLCNDCGQRLKRQiNACCPICRR 549

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