2EA5


Conserved Protein Domain Family
mRING-HC-C3HC5_CGRF1

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cd16787: mRING-HC-C3HC5_CGRF1 
Click on image for an interactive view with Cn3D
Modified RING finger, HC subclass (C3HC5-type), found in cell growth regulator with RING finger domain protein 1 (CGRRF1) and similar proteins
CGRRF1, also known as cell growth regulatory gene 19 protein (CGR19) or RING finger protein 197 (RNF197), functions as a novel biomarker of tissue monitor endometrial sensitivity and response to insulin-sensitizing drugs, such as metformin, in the context of obesity. CGRRF1 contains a C-terminal modified C3HC5-type RING-HC finger, which is distinguished from typical C3HC4 RING-HC finger due to the existence of the additional cysteine residue in the middle portion of the RING finger domain.
Statistics
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PSSM-Id: 319701
View PSSM: cd16787
Aligned: 21 rows
Threshold Bit Score: 60.0219
Threshold Setting Gi: 24585479
Created: 3-May-2013
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding sitemodified
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Structure:2EA5; Homo sapiens CGRF1 binds two Zn2+ ions through its modified C3HC5-type RING-HC finger.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
Feature 1         #  #           # #   #  #          #  # 
2EA5_A        17 DCVVCQNgtvnwVLLPCRHTCLCDGCVKYFq----qCPMCR 53
gi 242020236 255 LCVVCQYfplsrALLPCRHTCVCSVCFEKLd----rCPMCR 291
gi 405975260 183 SCCVCQDaemtiVLLPCRHGCVCSGCVAKLd----kCPVCR 219
gi 215499408 158 LCVVCQAssathALLPCRHTCVCGACFSKLd----aCPMCR 194
gi 443702480 240 QCVVCIStavqrVIMPCRHACVCSECFGRLp----rCPMCQ 276
gi 225714144 226 ECVVCQEnpitrAFLPCRHACSCSDCFKRIkn---kCPMCR 263
gi 66813674  731 TCVVCVDllintVLVPCRHSCICSTCSKKLs----lCPLCR 767
gi 161789048 896 SCVICASnppniVLLPCRHSSLCSDCCSKLt----kCPICR 932
gi 472461872 151 LCVICTTdpreiLLLPCRHITMCAGCYEEVkerthqCPICR 191
gi 253745465 476 ECVVCLSrpkniKLDPCKHVCICHECYLQLld--krCPICR 514

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