Conserved Protein Domain Family
SP-RING_ZMIZ

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cd16791: SP-RING_ZMIZ 
SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
This family includes Zmiz1 (Zimp10) and its homolog Zmiz2 (Zimp7), both of which were initially identified in humans as androgen receptor (AR) interacting proteins and function as transcriptional co-activators. They interact with BRG1, the catalytic subunit of the SWI-SNF remodeling complex. They also associate with other hormone nuclear receptors and transcription factors, such as p53 and Smad3/Smad4, and regulate transcription of specific target genes by altering their chromatin structure. The family also includes tonalli (Tna), an ortholog identified in Drosophila. It genetically interacts with the ATP-dependent SWI/SNF and Mediator complexes, suggesting a potential role for the Zmiz proteins in chromatin remodeling. Zmiz proteins contain a highly conserved Siz/PIAS (protein inhibitor of activated signal transducer and activator of transcription) RING (SP-RING) finger, also known as msx-interacting zinc finger (Miz domain), and a strong transactivation domain within the C-terminus. The SP-RING/Miz domain is highly conserved in members of the PIAS family and confers SUMO-conjugating activity. It is a variant of RING finger, which lacks the second, fifth, and sixth zinc-binding residues of the consensus C3H2C3-/C3HC4-type RING fingers. The strong intrinsic transactivation domain facilitates Zmiz proteins to augment the transcriptional activity of nuclear hormone receptors and other transcriptional factors. They may act as transcriptional co-regulators.
Statistics
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PSSM-Id: 319705
View PSSM: cd16791
Aligned: 13 rows
Threshold Bit Score: 103.708
Threshold Setting Gi: 828218972
Created: 22-Mar-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteSP-RING finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens E3 Sumo Ligase Pias2 (4FO9) binds one Zn2+ ion through its SP-RING finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
Feature 1                            # #                    #  #  
gi 56404909   597 SLKCPITFRRIQLPARGHDCRHIQCFDLESYLQLNCERgTWRCPVCNK 644
gi 405976456  555 SLKCPITFRRIMLPARGHECKHIQCFDLESYLQLNTERgSWRCPVCSK 602
gi 215490764  538 QLKCPITFKRITLPARGQECKHIQCFDLESYLQLNCERgSWRCPVCSK 585
gi 443717152  209 SLKCPITYRRISLPARGHDCKHIQCFDLESYLQMNSERgTWRCPVCNK 256
gi 761902704  415 SLKCPITFKRIQLPARGADCKHIQCFDLQSYLQLNCDRgTWRCPVCNN 462
gi 56404979   739 SLKCPITFRRIQLPARGHDCKHVQCFDLESYLQLNCERgTWRCPVCNK 786
gi 780006557  700 SLKCPITYKRITLPARGHDCKHIQCFDLESYLQLNCERgSWRCPVCKX 747
gi 919093917  713 SLKCPITFRRITLPARGHDCKHIQCFDLESYLQLNCERgAWRCPVCNK 760
gi 193211606  718 SLRCPITYTRIKIPARGKDCKHIQCFDLESYLQMNSDNaTWRCPICHK 765
gi 45550589   741 SLKCPITKSRIRLPARGHECKHVQCFDLEAYLMINSERgSWRCPECSK 788
gi 229299098  844 SLKCPITFRRIQLPARGHDCKHIQCFDLESYLQLNCERgQWRCPVCNK 891
gi 828218972  821 SLKCRITYQKINIPARGQECKHIQCFDLETYLKLNVDKvNWKCPVCSK 868
gi 632978055  681 SLKCPITFRRIQLPARGHDCKHIQCFDLESYLQLNCERgTWRCPVCNK 728

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