Conserved Protein Domain Family
dRING_RMD5B
?
cd16795: dRING_RMD5B 
Degenerated RING finger found in protein RMD5 homolog B (RMD5B)
RMD5B is one of the vertebrate homologs of yeast Rmd5p. The biological function of RMD5B remains unclear. RMD5B contains a Lissencephaly type-1-like homology motif (LisH), a C-terminal to LisH motif (CTLH) domain, and a degenerated RING finger that is characterized by lacking the second, fifth, and sixth Zn2+ ion-coordinating residues compared with the classic C3H2C3-/C3HC4-type RING fingers.
Links
?
Statistics
?
PSSM-Id: 438449
Aligned: 5 rows
Threshold Bit Score: 138.993
Created: 14-Apr-2015
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Download Cn3D
Conserved Features/SitesClick to see Conserved Features Help
 
Zn binding site
Feature 1: Zn binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:C H C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:The degenerated RING finger is characterized by lacking the second, fifth, and sixth Zn2+ ion-coordinating residues compared with the classic C3H2C3-/C3HC4-type RING fingers, similar to SP-RING fingers.
  • Comment:based on the structures of human Sumo ligases Pias2 and Pias3 with bound Zn2+ ion through their SP-RING fingers
  • Comment:The SP-RING finger is a variant of RING finger; it binds a single Zn ion and lacks the second, fifth, and sixth zinc-binding residues of the consensus C3H2C3-/C3HC4-type RING fingers.
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                             # #                 #  #              
Q96G75       335 VFACPILRQQTSDSNPPIKLICGHVISRDALNKLiNGGKLKCPYCPMEQNPADGKRIIF 393 human
XP_007889532 334 VFACPILRQQATDSNPPMKLICGHVISRDALNKLiNGGKLKCPYCPMEQAPADAKQIYF 392 elephant shark
EMP30930     387 VFACPILRQQTTDSNPPIKLICGHVISRDALNKLiNGGKLKCPYCPMEQNPADGKRIIF 445 green sea turtle
AAQ94562     332 VFACPILRQQTSESNPPMKLICGHVISRDALNKLtNAGKLKCPYCPMEQNPSDAKQIYF 390 zebrafish
XP_005992441 334 VFACPILRQQTTDSNPPMKLICGHVISRDALNKLnIAGKLKCPYCPMEQNPADAKRIYF 392 coelacanth

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap