Conserved Protein Domain Family
RING-H2_RNF13

?
cd16796: RING-H2_RNF13 
RING finger, H2 subclass, found in RING finger protein 13 (RNF13) and similar proteins
RING finger, H2 subclass, found in RING finger protein 13 (RNF13) and similar proteins RNF13 is a widely expressed membrane-associated E3 ubiquitin-protein ligase that is functionally significant in the regulation of cancer development, muscle cell growth, and neuronal development. Its expression is developmentally regulated during myogenesis and is upregulated in various tumors. RNF13 negatively regulates cell proliferation through its E3 ligase activity. It functions as an important regulator of Inositol-requiring transmembrane kinase/endonuclease IRE1alpha, mediating endoplasmic reticulum (ER) stress-induced apoptosis through the activation of the IRE1alpha-TRAF2-JNK signaling pathway. Moreover, RNF13 is involved in the regulation of the soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor (SNARE) complex via the ubiquitination of snapin, a SNAP25-interacting protein, which thereby controls synaptic function. In addition, RNF13 participates in regulating the function of satellite cells by modulating cytokine composition. RNF13 is evolutionarily conserved among many metazoans and contains an N-terminal signal peptide, a protease-associated (PA) domain, a transmembrane (TM) domain and a C-terminal C3H2C3-type RING-H2 finger domain followed by a putative PEST sequence.
Statistics
?
PSSM-Id: 319710
View PSSM: cd16796
Aligned: 5 rows
Threshold Bit Score: 103.586
Threshold Setting Gi: 148222567
Created: 23-Mar-2015
Updated: 18-Aug-2016
Structure
?
Aligned Rows:
 
Zn binding siteRING-H2 finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Mus musculus RNF126 (2ECT) binds two Zn2+ ions through its RING-H2 finger.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
Feature 1           #  #              # #  #  #           #  #    
gi 21362880  237 YDVCAICLDEYeDGDKLRILPCSHAYHCKCVDPWLTKTKKTCPVCKQKV 285
gi 41054856  237 YDVCAICLDEYeEGERLRVLPCSHAYHCKCVDPWLTKTKKTCPVCKQKV 285
gi 148222567 237 YDVCAVCLDEYeEGDKLRILPCSHAYHCKCVDPWLTKTKKTCPVCKQKV 285
gi 21362882  237 YDVCAICLDEYeDGDKLRILPCSHAYHCKCVDPWLTKTKKTCPVCKQKV 285
gi 556983855 234 YDVCAICLDEYeEGDKLRILPCAHAYHCKCVDPWLTKTKKTCPVCKQRV 282

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap