Conserved Protein Domain Family
RING-H2_ZNRF3

?
cd16799: RING-H2_ZNRF3 
RING finger, H2 subclass, found in zinc/RING finger protein 3 (ZNRF3) and similar proteins
ZNRF3, also known as RING finger protein 203 (RNF203), is a homolog of Ring finger protein 43 (RNF43). It is a transmembrane E3 ubiquitin-protein ligase that is associated with the Wnt receptor complex, and negatively regulates Wnt signaling by promoting the turnover of frizzled and lipoprotein receptor-related protein LRP6 in an R-spondin-sensitive manner. It inhibits gastric cancer cell growth and promotes the cell apoptosis by affecting the Wnt/beta-catenin/TCF signaling pathway. ZNRF3 contains an N-terminal signal peptide, a protease-associated (PA) domain, a transmembrane (TM) domain and a C3H2C3-type RING-H2 finger domain followed by a long C-terminal region.
Statistics
?
PSSM-Id: 319713
View PSSM: cd16799
Aligned: 5 rows
Threshold Bit Score: 97.0179
Threshold Setting Gi: 395455178
Created: 2-May-2013
Updated: 18-Aug-2016
Structure
?
Aligned Rows:
 
Zn binding siteRING-H2 finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Mus musculus RNF126 (2ECT) binds two Zn2+ ions through its RING-H2 finger.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
Feature 1         #  #              # #  #  #          #  #   
gi 126253847 292 DCAICLEKYiDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRHN 336
gi 483498986 195 DCAICLEKYiDGEELRVIPCTHRFHKKCVDPWLLQHHTCPHCRHN 239
gi 395455178 266 DCAICLEKYiDGEELRVIPCAHRFHKKCVDPWLLQHHTCPHCRHN 310
gi 123904520 201 DCAICLEKYiDGEELRVIPCTHRFHKRCVDPWLLQNHTCPHCRHN 245
gi 632962471 192 DCAICLEKYlDGEELRVIPCTHRFHKKCVDPWLLQHHTCPHCRHN 236

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap