Conserved Protein Domain Family
RING-H2_RNF115

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cd16800: RING-H2_RNF115 
RING finger, H2 subclass, found in RING finger protein 115 (RNF115) and similar proteins
RNF115, also known as Rab7-interacting ring finger protein (Rabring 7), or zinc finger protein 364 (ZNF364), or breast cancer-associated gene 2 (BCA2), is an E3 ubiquitin-protein ligase that is an endogenous inhibitor of adenosine monophosphate-activated protein kinase (AMPK) activation and its inhibition increases the efficacy of metformin in breast cancer cells. It also functions as a co-factor in the restriction imposed by tetherin on HIV-1, and targets HIV-1 Gag for lysosomal degradation, impairing virus assembly and release, in a tetherin-independent manner. Moreover, RNF115 is a Rab7-binding protein that stimulates c-Myc degradation through mono-ubiquitination of MM-1. It also plays crucial roles as a Rab7 target protein in vesicle traffic to late endosome/lysosome and lysosome biogenesis. Furthermore, RNF115 and the related protein, RNF126 associate with the epidermal growth factor receptor (EGFR) and promote ubiquitylation of EGFR, suggesting they play a role in the ubiquitin-dependent sorting and downregulation of membrane receptors. RNF115 contains an N-terminal BCA2 Zinc-finger domain (BZF), the AKT-phosphorylation sites, and the C-terminal C3H2C3-type RING-H2 finger.
Statistics
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PSSM-Id: 319714
View PSSM: cd16800
Aligned: 5 rows
Threshold Bit Score: 107.769
Threshold Setting Gi: 591380255
Created: 24-Mar-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-H2 finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structure evidence that Mus musculus RNF126 (2ECT) binds two Zn2+ ions through its RING-H2 finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
Feature 1          #  #              # #  #  #          #  #    
gi 56405389  226 LECPVCKEDYTVeEEVRQLPCNHFFHSSCIVPWLELHDTCPVCRKSL 272
gi 591380255 213 LECPVCKEDYTVtEQVRQLPCNHFFHSNCIVPWLELHDTCPVCRKSL 259
gi 121583717 236 MECPVCKEDYTVgEPVRQLPCNHFFHSDCIVPWLELHDTCPVCRKSL 282
gi 147906635 219 LECPVCKEDYTVeEQVRQLPCNHFFHGDCIVPWLELHDTCPVCRKSL 265
gi 632991351 101 LDCPVCKEDFQLrEQVRQLPCNHFFHSDCIVPWLQLHDTCPVCRKSL 147

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