Conserved Protein Domain Family
RING-H2_RNF130

?
cd16803: RING-H2_RNF130 
RING finger, H2 subclass, found in RING finger protein 130 (RNF130) and similar proteins
RNF130, also known as Goliath homolog (H-Goliath), is a paralog of RNF128, also known as gene related to anergy in lymphocytes protein (GRAIL). It is a transmembrane E3 ubiquitin-protein ligase expressed in leukocytes. It has a self-ubiquitination property, and controls the development of T cell clonal anergy by ubiquitination. RNF130 contains an N-terminal signal peptide, a protease-associated (PA) domain, a transmembrane (TM) domain and a C-terminal C3H2C3-type RING-H2 finger domain followed by a putative PEST sequence.
Statistics
?
PSSM-Id: 319717
View PSSM: cd16803
Aligned: 6 rows
Threshold Bit Score: 120.077
Threshold Setting Gi: 134024402
Created: 19-Mar-2015
Updated: 18-Aug-2016
Structure
?
Aligned Rows:
 
Zn binding siteRING-H2 finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Mus musculus RNF126 (2ECT) binds two Zn2+ ions through its RING-H2 finger.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
Feature 1          #  #              # #  #  #          #  #      
gi 56749089  262 DHCAVCIESYKqnDVVRILPCKHVFHKSCVDPWLsEHCTCPMCKLNILK 310
gi 556952636 266 DHCAVCIEGYKlnDVVRILPCKHVFHKNCVDPWLnEQCTCPMCKLNILK 314
gi 678193991 274 DHCAVCIESYKqnDVVRILPCKHVFHKACVDPWLsEHCTCPMCKLNILK 322
gi 632979169 272 DHCAVCIEGYKsnDVVRILPCKHLFHKSCVDPWLnEHCTCPICKLNILK 320
gi 66392140  235 NHCAVCIEGYQlnDVVRILPCKHVFHKMCVDPWLnEHCTCPMCKLNILK 283
gi 134024402 267 DHCAVCIESYKqnDIVRVLPCKHVFHKVCVDPWLsEHCTCPMCKLNILK 315

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap