Conserved Protein Domain Family
RING-H2_RNF149

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cd16804: RING-H2_RNF149 
RING finger, H2 subclass, found in RING finger protein 149 (RNF149) and similar proteins
RNF149, also known as DNA polymerase-transactivated protein 2, is an E3 ubiquitin-protein ligase that interacts with wild-type v-Raf murine sarcoma viral oncogene homolog B1 (BRAF), a RING domain-containing E3 ubiquitin ligase involved in control of gene transcription, translation, cytoskeletal organization, cell adhesion, and epithelial development. RNF149 induces the ubiquitination of wild-type BRAF and promotes its proteasome-dependent degradation. Mutated RNF149 has been found in some human breast, ovarian, and colorectal cancers. RNF149 contains an N-terminal signal peptide, a protease-associated (PA) domain, a transmembrane (TM) domain and a C-terminal C3H2C3-type RING-H2 finger domain followed by a putative PEST sequence.
Statistics
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PSSM-Id: 319718
View PSSM: cd16804
Aligned: 5 rows
Threshold Bit Score: 112.295
Threshold Setting Gi: 632939890
Created: 19-Mar-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-H2 finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Mus musculus RNF126 (2ECT) binds two Zn2+ ions through its RING-H2 finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
Feature 1         #  #              # #  #  #          #  #      
gi 160332298 268 NCAVCIENFKvKDIIRILPCKHIFHRICIDPWLLDHRTCPMCKLDVIK 315
gi 557000352 297 NCAVCIENYKpKDVVRILPCKHVFHRSCIDPWLLEHRTCPMCKLDVIK 344
gi 82185311  263 NCAVCIENYKtKDLVRILPCKHIFHRLCIDPWLIEHRTCPMCKLDVIK 310
gi 632939890 278 GCAVCIEVYRsRDVVRILPCKHVFHRICIDPWLLEHQTCPMCKLDVIK 325
gi 591349009 203 NCAVCIENYKpKDIVRILPCKHIFHRTCIDPWLLDHRTCPMCKLDVIK 250

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