Conserved Protein Domain Family
RING_CH-C4HC3_MARCH7

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cd16812: RING_CH-C4HC3_MARCH7 
RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH7 (MARCH7)
MARCH7, also known as membrane-associated RING finger protein 7, membrane-associated RING-CH protein VII (MARCH-VII), RING finger protein 177 (RNF177), or axotrophin, is a ubiquitin E3 ligase expressed in multiple types of cells and tissues, including stem cells and precursor cells, and is predominantly localized on the plasma membrane and cytoplasm. MARCH7 is involved in T cell proliferation and neuronal development. It also participates in the regulation of cytoskeleton re-organization, cellular migration and invasion, cell proliferation, and tumorigenesis in ovarian carcinoma cells. Moreover, MARCH7 modulates nuclear factor kappaB (NF-kappaB) and Wnt/beta-catenin pathways. It has been identified as an authentic target of miR-101. Furthermore, ubiquitinates tau protein in vitro impairing microtubule binding. Unlike other MARCH proteins, MARCH7 is predicted to have no transmembrane spanning region. It harbors a C4HC3-type RING-CH finger, also known as vRING or RINGv, a variant of C3H2C3-type RING-H2 finger, that is responsible for its E3 activity.
Statistics
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PSSM-Id: 319726
View PSSM: cd16812
Aligned: 5 rows
Threshold Bit Score: 130.839
Threshold Setting Gi: 74762745
Created: 20-Mar-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-CH finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens MARCH8 (2D8S) binds two Zn2+ ions through its RING-CH finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
Feature 1              #  #              # #       #  #                    #  #   
gi 74762745  546 EEEGDLCRICQMAaassSNLLIEPCKCTGSLQYVHQDCMKKWLQAKINSGSSLeAVTTCELCKEK 610
gi 676416830 540 DEEGDLCRICQMSsassDNLLIEPCKCTGSLQYVHQECMKKWLKSKINSGSSLeAVTTCELCKEK 604
gi 301129246 599 EEEGDLCRICQMGeqwsSNPLIEPCKCTGSLQYVHQDCIKKWLRSKISSGSNLeAITTCELCKEK 663
gi 512865946 582 EEEGDLCRICQTGmttpSNPFIEPCKCSGSLQYVHQDCMKKWLIAKIDSGSSLdSVTTCELCKET 646
gi 632945341 644 EDEGDLCRICQIGtsssSNPLIQPCNCNGSLQYVHQECVKKWLQSKINSGADLtAVTICELCKEK 708

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